Intro To cancer Chemo: Nausea and Vomiting Flashcards
Ondansetron Mechanism
5-HT3-R Antagonist
Ondansetron Use
Acute N/V
high emetogenic cancer: cisplatin, carmustine, cyclophosphamide
add dexamethasone to improve efficacy
Granisetron Mechanism
5-HT3-R Antagonist
Granisetron Use
Acute N/V
High emetogenic Cancer: Cisplatin, Carmustine, Cyclophosphamide
add dexamethasone to improve efficacy
Prochloroperazine Mechanism
D2-R Antagonist
Prochloroperazine use
acute N/V
Metoclopramide Mechanism
D2-R Antagonist
Metoclopramide Use
Acute N/V
Aprepitat Mechanism
Oral: NK1-R Antagonist
Aprepitat use
delayed N/V
can use with 5-HT3-R Antagonist
Fosaprepitant Mechanism
IV NK1-R antagonist
Fosaprepitant use
delayed N/V
can be used with 5-HT3-R antagonist
Corticosteroid drugs
Prednisone
Prednisolone
Hydrocortisone
Dexamethasone
Corticosteroid mechanism
Suppress activation of T Cells via nF-KB inhibition
decrease cytokine production
direct cytotoxicity to subsets of T and B Cells
Corticosteroid Use
Adjunct: Leukemia, Malignant Lymphona, N/V
Prednisone: MOPP for HL, CHOP for NHL
