Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

pharmacology > Targeted Cancer Therapy: Monoclonal Antibodies > Flashcards

Targeted Cancer Therapy: Monoclonal Antibodies Flashcards

1
Q

Trastuzumab Mechanism

A

Bind EC domain of HER2

inhibit cancer cell proliferation

directly cause apoptosis in cells which overexpress HER2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Trastuzumab use

A

HER2+ Breast Cancer and gastric cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Trastuzumab Side Effects

A

dilated cardiomyopathy

hypersensitivity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Cetuximab Mechanism

A

Selectively bind EGFG: inhibit EGFR-L

inhibits cell growth: induce apoptosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Cetuximab Use

A

Metastatic Colorectal Cancer
Head and Neck Cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Cetuximab Side Effects

A

Acne-like rash
diarrhea
elevated LFT’s

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Panitumumab Mechanism

A

Selectively bind EGFG: inhibit EGFR-L

inhibits cell growth: induce apoptosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Panitumumab Use

A

Metastatic Colorectal Cancer
Head and Neck Cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Panitumumab Side Effects

A

Acne-like rash
diarrhea
elevated LFT’s

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Ritixumab Mechanism

A

Bind CD20 on Cancerous B Cells

recruits immune effectors

mediate B Cell Lysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Ritixumab Use

A

CD20+ NHL

other CD20+ cancers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Rituximab Side Effects

A

Risk of PML with JC Virus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Bevacizumab Mechanism

A

Directly bind VEGF and inhibits stimulation of new vessel formation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Bevacizumab Use

A

initial treatment of solid tumors
Metastatic colorectal cancer
RCC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Bevacizumab Side Effects

A

hemorrhage
clots
GI Perforation
impaired wound healing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Ipilimumab Mechanism

A

Anti CTLA-4 Inhibitor

17
Q

Ipilimumab Use

A

Melanoma

18
Q

Ipilimumab Side Effects

A

Rash
GI discomfort

19
Q

Pembrolizumab Mechanism

A

blocks PD-1 and its ligand

inhibit T Cell proliferation and cytokine production

20
Q

Pembrolizuman Use

A

Melanoma (nodes)
urothelial carcinoma
NSCLC

21
Q

Pembrolizumab Side Effects

A

Hepatitis
Dermatitis
Enterocolitis
Pneumonitis

22
Q

Nivolumab Mechanism

A

blocks PD-1 and its ligand

inhibit T Cell proliferation and cytokine production

23
Q

Nivolumab Use

A

Melanoma (nodes)
urothelial carcinoma
NSCLC

24
Q

Nivolumab Side Effects

A

Hepatitis
Dermatitis
Enterocolitis
Pneumonitis

25
Q

Cemiplimab Mechanism

A

blocks PD-1 and its ligand

inhibit T Cell proliferation and cytokine production

26
Q

Cemplimab Use

A

Melanoma (nodes)
urothelial carcinoma
NSCLC

27
Q

Cemplimab Side Effects

A

Hepatitis
Dermatitis
Enterocolitis
Pneumonitis

28
Q

Atezolizumab Mechanism

A

binds PD-L1

prevents interaction with CD1 and CD80 co receptors

inhibits immune response

29
Q

Atezolizumab use

A

Melanoma (Nodes)
Urothelial Carcinoma
NSCLC

30
Q

Atezolizumab Side Effects

A

Hepatitis
Dermatitis
Enterocolitis
Pneumonitis

31
Q

Durvalumab Mechanism

A

binds PD-L1

prevents interaction with CD1 and CD80 co receptors

inhibits immune response

32
Q

Durvalumab Use

A

Melanoma (Nodes)
Urothelial Carcinoma
NSCLC

33
Q

Durvalumab Side Effects

A

Hepatitis
Dermatitis
Enterocolitis
Pneumonitis

34
Q

Avelumab Mechanism

A

binds PD-L1

prevents interaction with CD1 and CD80 co receptors

inhibits immune response

35
Q

Avelumab Use

A

Melanoma (Nodes)
Urothelial Carcinoma
NSCLC

36
Q

Avelumab Side Effects

A

Hepatitis
Dermatitis
Enterocolitis
Pneumonitis

pharmacology (18 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions