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Pharmacology > Hormonal Cancer Management > Flashcards

Hormonal Cancer Management Flashcards

1
Q

Selective Estrogen Receptor modulator Drugs

A

Tamoxifen
Raloxifene

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2
Q

Tamoxifen Mechanism

A

Block Estrogen-R
antagonist to estradiol
partial agonist in uterus

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3
Q

Tamoxifen Use

A

ER positive tumors

prevent breast cancer

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4
Q

Tamoxifen Side Effects

A

Risk of endometrial cancer
hot flashes

thromboembolic events (DVT)

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5
Q

Raloxifene Mechanism

A

Block Estrogen-R
antagonist to estradiol
partial agonist in bone

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6
Q

Raloxifene Use

A

prevent breast cancer

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7
Q

Raloxifene Side Effects

A

Increase Thromboembolic events (DVT)

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8
Q

Fulvestrant mechanism

A

Selective Estrogen Receptor Downregulator (SERD)

binds Estrogen-R with high affinity to decrease receptor numbers

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9
Q

Fulvestrant Use

A

ER positive breast cancer

follows tamoxifen when it is no longer effective

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10
Q

Fulvestrant Side Effects

A

N/V
Hot Flashes
GI symptoms

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11
Q

Aromatase Inhibitor Drugs

A

Anastrozole
Letrozole(non-steroidal)
Exemestane(steroid: non-reversible)

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12
Q

Anastrozole Mechanism

A

Convert Androstenedion and testosterone into estrone and estradiol

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13
Q

Anastrozole Use

A

First line in menopausal women with ER positive breast cancer who cannot tolerate Tamoxifen

5 years of Tamoxifen followed by 2.5 years of aromatase inhibitor

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14
Q

Anastrozole Side Effects

A

N/V

hot flashes, fatigue

risk bone loss and fracture

Less than thrombosis than Tamoxifen

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15
Q

Letrozole Mechanism

A

Non-steroidal

Convert Androstenedion and testosterone into estrone and estradiol

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16
Q

Letrozole Use

A

First line in menopausal women with ER positive breast cancer who cannot tolerate Tamoxifen

5 years of Tamoxifen followed by 2.5 years of aromatase inhibitor

17
Q

Letrozole Side Effects

A

N/V

hot flashes, fatigue

risk bone loss and fracture

Less than thrombosis than Tamoxifen

18
Q

Exemestane Mechanism

A

steroidal: irreversibel inhibitor

Non-steroidal

Convert Androstenedion and testosterone into estrone and estradiol

19
Q

Exemestane Use

A

First line in menopausal women with ER positive breast cancer who cannot tolerate Tamoxifen

5 years of Tamoxifen followed by 2.5 years of aromatase inhibitor

20
Q

Exemestane Side Effects

A

N/V

hot flashes, fatigue

risk bone loss and fracture

Less than thrombosis than Tamoxifen

21
Q

Megestrol Acetate Mechanism

A

Lower LH
Anti-leutenizing effect at Pituitary

22
Q

Megestrol Acetate Use

A

Treat Palliative endometrial cancer

23
Q

Megestrol Acetate Side Effects

A

Edema

Thromboembolic Risk

24
Q

Leutenizing Hormone Release Hormone Receptor Agonist Drugs (LHRH)

A

Leuprolide

Goserelin

25
Q

Leuprolide Mechanism

A

bind LHRH-R

Suppress estrogen and androgen synthesis

26
Q

Leuprolide Use

A

Prostat Cancer
Endometriosis

with Flutamide to block tumor flare

27
Q

Leuprolide side effects

A

hypogonadism, decreased libido
ED
N/V

28
Q

Goserelin mechanism

A

bind LHRH-R

Suppress estrogen and androgen synthesis

29
Q

Goserelin Use

A

Prostat Cancer
Endometriosis

with Flutamide to block tumor flare

30
Q

Goserelin Side effects

A

hypogonadism, decreased libido
ED
N/V

31
Q

Flutamide Mechanism

A

Noncompetitive antagonist at androgen-R

32
Q

Flutamide Use

A

Prostate Carcinoma

33
Q

Flutamide Side effects

A

Gyno
Sexual Dysfunction

34
Q

Bicalutamide Mechanism

A

Noncompetitive antagonist at androgen-R

35
Q

Bicalutamide Use

A

prostate carcinoma

36
Q

Bicalutamide Side Effects

A

Gyno
Sexual Dysfunction

Pharmacology (18 decks)

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