2 Exo Panc and salivary gland [1] Flashcards Preview

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Flashcards in 2 Exo Panc and salivary gland [1] Deck (23):
1

6 main constituents of saliva and their fxn

water
HCO3
Mucin
Amylase
Lysozyme, lactoferrin, IgA
Epidermal and nerve growth factors

2

Starch and fat digestion begins in the mouth with these two enzymes

amylase
lingual lipase

3

structure of salivary gland

Acini secrete fluid, electrolyte, enzymes
-bascially makes the saliva

Acini → intercalated duct → striated duct

Striated duct modifies the saliva

4

Myoepithelial cells of salivary gland↓

only found in salivary gland (not pancreatic)
- contractile muscle cells that facilitate secretion into acinus + intercalated ducts

Vomiting: need fast secretions

5

In saliva, as flow rate ↑s, NaCl reabsorption _____

↓s

no time to modify in striated ducts
More Na+ in Saliva (slightly hypotonic close to isotonic)
Rich in HCO3 (more secreted with faster flow)

6

In saliva, as flow rate ↓s, NaCl reabsorption _____

↑s

got time to adjust
lots of NaCl reabsorption - less NaCl in saliva
- HCO3- and K+ ions are secreted

7

Regulation of pancreatic secretions:
ACh is released from _____ nerves.
It stimulates the release of ______ enzymes from _____ cells

vagus and ENS
digestive enzymes, acinar cells

8

Regulation of pancreatic secretions:
Secretin is released from ______ cells in the ______ intestines in response to acid. It stimulates the release of ______ from ______ cells

endocrine cells
Proximal small intestines
a HCO3 rich soln from pancreatic duct cells

(the release of secretin is enhanced by CCK)
(it acts by increasing cAMP levels in the duct cells)

9

Regulation of pancreatic secretions:
CCK is released from _____ cells in the ________ in response to fats and proteins. It stimulates the release of ______ from ______ cells but has other effects in the duodenum

endocrine cells (like secretin)
Proximal small intestines (like secretin)
digestive enzymes from acinar cells (like ACh)

10

diff between Salivary and pancreatic secretion regulations

Salivary secretion is regulated by ANS
Pancreatic secretion is regulated by ANS and Hormones

11

Salivary acinus is very vascular. Increase in blood flow results in (pick one) concentrated/dilute saliva, that is modified by ____ cells

dilute
duct cells
- salivary ducts are fairly impermeable to water

12

which is more vascular, salivary acini or pancreatic acini?

salivary - responds to blood flow

(pancreatic acini are not as vascular and respond to ACh and CCK)

13

Ductal cells of the pancrease secrete what in response to secretin?

Water and Bicarb
(salivary ducts are not very permeable to water)

14

KHCO3 and NaHCO3 is rich in which juices, salivary or pancreatic?

KHCO3: saliva
(remember K+ and HCO3 are secreted with low flow into saliva)

NaHCO3: pancreas

15

Inactive proteases secreted by pancreas

Trypsinogen
Chymotrypsinogen

Proleastase
procarboxypeptidase

16

CCK is released from endocrine cells, what effect does it have on:
Gallbladder →
Pancreas →
Stomach →
Sphincter of Oddi →

Gallbladder → contraction
Pancreas → acinar secretion
Stomach → reduced emptying
(CCK indicates more food digestion than nl is necessary)
Sphincter of Oddi → relaxation (to release bile)

17

8 different infxn/immunological salivary gland diseases

1. mumps
2. cytomegaloviral sialadenitis : inflmn of salivary gland
3. bacterial sialadenitis: bact. infxn of sal gland
4. sarcoidosis
5. sjogren's syndrome
6. salivary lymphoepithelial lesion
7. xerostomia or dry mouth
8. Halitosis

18

Benign salivary neoplasms

1. mixed tumor (pleomorphic adenoma) sessile
2. Monomorphic adenoma
3. ductal papilloma

19

Warthin's tumor

benign papillary cystadenoma lymphomatosum
second most benign tumor of parotid gland

both LYMPHOID and ONCOCYTIC epithelial elements must be present to dx warthins

WHALE: Warthins Has Abundant Lymphoid + Epithelial

20

Adenoid cystic carcinoma

swiss cheese pattern
second most common malignant tumor of salivary gland

Most common malignant tumor in submandibular, sublingual and MINOR salivary glands.

21

8 endocrine pancreatic cancer

1. gastrinoma (ZE synd)
2. glucagonoma
3. insulinoma
4. nonfxnal islet cell tumor (NICT)
5. somatostatinoma
6. VIP releasing tumor

22

Insulinoma

most common pancreatic neuroendocrine tumor

23

8 Exocrine pancreatic cancer

1. acinar cell carcinoma
2. adenocarcinoma
3. adenosquamous carcinoma
4. intraductal papillary mucinous neoplasm
5. Mucinous cystadenocarcinoma
6. pancreatoblastoma