fxnl Histo of Liver [1] Flashcards Preview

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Flashcards in fxnl Histo of Liver [1] Deck (10):
1

Liver receives 70-75% of blood supplies from

hepatic portal vein

2

porta hepatis

hepatic portal vein and hepatic artery enter liver with bile duct through porta hepatis

3

Classic lobule

anastomosing plates of hepatocytes arranged radially around a CENTRAL VEIN
- Interlobular vessels (2 types) are located at the 6 vertices to carry incoming blood from both hepatic portal vein and hepatic artery

Interlobular vessels (artery and vein) + bile duct + lymphatic space (space of mall) → portal triad

4

Portal lobule

triangle shape between 3 central veins
- zone of tissue around a BILE DUCT in which a group of bile canaliculi feed

Bile secretory fxnal unit

5

Acinar lobule

short axis between 2 portal triads and a
long axis between 2 central veins

Blood delivery unit

6

with the acinar lobule, which zone gets affected first
Oxygen deprivation
Toxins

Oxygen deprivation/Ischemia
- zone 3: around central vein will die first
(vessels need oxygen)


Toxins
- zone 1: near the septa will die first
(near distributing vessels)

7

Bile flow

Bile canaliculi →
small bile ductules (canals of hering) →
interlobular bile ducts (of portal triad)→
lobar ducts →
common hepatic duct

8

fxns of hepatocytes

1. take up glucose → stores as glycogen
2. produce albumin
3. produce clotting glycoproteins (fibrinogen+prothrombin)
4. produces lipoproteins
5. take up lipid soluble TOXINS from gut and BILIRUBIN from spleen and detoxify them through conjugating them with glucoronic acid and then eliminate excess cholesterol in bile

9

Kupffer cells

macrophages that also forms fenestrated endothelial layer (like sinusoids) adjacent to hepatocytes
- large nuclei and phagocytose material

10

Gallbladder
- structure

- Mucosal layer is extensively folded
- Has columnar epithelium adjacent to lumen with microvilli and tight jxns
- Folded basolateral surfaces to transport salt and water
- LP has lymphocytes and plasma cells
- Muscularis externa has smooth muscles
- Outer adventitia has large blood vessels in CT and adipose tissue

(looks like SI with lots of muscle)