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Flashcards in 2 Lower GI pharm [3] Deck (9):
1

1st choice fiber/bulk forming ____ approximate physiological mechnism by ______ and _____ via absorption of water and subsequent bulk expansion. We must use ______ since they can interact with other drugs.

psyllium.
facilitate passage and stimulate peristalsis
space dosing

2

Docusate

Mineral oil

surfactant: stool softener with PREVENTION as primary role

Lubricant: coats fecal contents to prevent colonic absorption of fecal water

3

saline/Osmotic cathartics
- example

non-absorbable ions → osmotic retention of intestinal water → increased peristalsis

polyethylene glycol (miralax): high volume for BOWEL CLEANSING prior to procedures (prevent net transfer of electrolytes into lumen or small volume for CONSTIPATION
- can lead to electrolyte depletion in prolonged use.

4

If fiber/saline fails, you can use ________.
example.

stimulant-irritant laxatives

Bisacodyl: induce peristalsis by inducing low grade inflammation in the bowel → promote accumulation of water and electrolytes and stimulate intestinal motility

5

most widely abused class of laxatives

bisacodyl
- dangerous side effects: electrolyte/fluid deficiencies, severe cramping

6

Castor oil acts where in the GI? to do what?

acts in the small intestine → stimulate fluid/electrolyte secretion and speed intestinal transit

7

Loperimide

antidiarrheal/opioid (like polycarbophil)
- can help with cholera toxin
(only block downstream effect by decreasing secretion, not affecting the increase in cAMP happening upstream.
- effective for travelers diarrhea

8

polycarbophil

antidiarrheal/opiod (like loperimide)
safe for both diarrhea and constipation

9

Bismuth subsalicylate (pepto bismol)

absorbent agent
- absorb toxins that cause irritation, take after each loose bowel movement until diarrhea is controlled

- avoid in children under 12 due to increased risk for Reyes syndrome