Flashcards in 2 Lower GI pharm  Deck (9):
1st choice fiber/bulk forming ____ approximate physiological mechnism by ______ and _____ via absorption of water and subsequent bulk expansion. We must use ______ since they can interact with other drugs.
facilitate passage and stimulate peristalsis
surfactant: stool softener with PREVENTION as primary role
Lubricant: coats fecal contents to prevent colonic absorption of fecal water
non-absorbable ions → osmotic retention of intestinal water → increased peristalsis
polyethylene glycol (miralax): high volume for BOWEL CLEANSING prior to procedures (prevent net transfer of electrolytes into lumen or small volume for CONSTIPATION
- can lead to electrolyte depletion in prolonged use.
If fiber/saline fails, you can use ________.
Bisacodyl: induce peristalsis by inducing low grade inflammation in the bowel → promote accumulation of water and electrolytes and stimulate intestinal motility
most widely abused class of laxatives
- dangerous side effects: electrolyte/fluid deficiencies, severe cramping
Castor oil acts where in the GI? to do what?
acts in the small intestine → stimulate fluid/electrolyte secretion and speed intestinal transit
antidiarrheal/opioid (like polycarbophil)
- can help with cholera toxin
(only block downstream effect by decreasing secretion, not affecting the increase in cAMP happening upstream.
- effective for travelers diarrhea
antidiarrheal/opiod (like loperimide)
safe for both diarrhea and constipation