2 Intro to infectious Dis [3] Flashcards Preview

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Flashcards in 2 Intro to infectious Dis [3] Deck (10):
1

2 leading causes of death from infectious diseases world wide

Pneumonia (8-10%, 10 mil/year)

Diarrhea (2 mil/year)

2

Age group preferentially affected by infectious disease syndromes

diarrheal disease is in the young and old

3

Identify the leading cause of morbidity and death with diarrhea

dehydration
- rehydration is mainstay of therapy

4

Species that cause Noninflammatory diarrhea

Norwalk virus
rotavirus
giardia lamblia
cholera
ETEC

5

Species that cause inflammatory diarrhea

c. jejuni
shigella
salmonella
Ecoli 0157:H7
C. difficile
E. histolytica

6

Inflammatory vs noninflammatory diarrhea

Inflammatory:
- increase temp, WBC, RBC, involves the COLON

NON-inflammatory: (watery)
- involes the SMALL BOWEL

7

Structure of cholera toxin

A:5B

A - active: secretes toxin into epi cells
B - binding: binds to epi cells

8

Signs of dehydration

decrease pulse
low BP
poor skin turgor
sunken eyes
decreased urine
met acidosis
hypoglycemia
hypokalemia

9

Travelers diarrhea

Enterotoxigenic E. coli (ETEC)

10

Norovirus/Norwalk virus

family/community epidemics (winter) - like rota

transmitted thru: f-o, contamination, shellfish, and water

Older children and adults
(comes fast, goes away fast)