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Flashcards in Quiz 4 Reverse Deck (45):
1

III

What schedule drug are androgens?

2

1. Wt gain2. Gynecomastia3. Cardiac - HF4. Liver problems 5. Suppression of clotting factors - inc. in PT6. Balls shrink, dec. spermies, impotence, prostatic hypertrophy7. Uterine atrophy, boobs shrink, thickened vocal cords, masculinization of F fetus8. Inc. Hgb & Hct9. Inc. sebum = inc. acne10. Male pattern baldness

ADRs androgens

3

DHEA

What androgen can you buy OTC?

4

1. Estrogens2. Progestogens3. Androgens4. Glucocorticoids5. Mineralocorticoids

What 5 groups of molecules does the adrenal cortex secrete?

5

Pts receiving 20mg/day or more of prednisone (or equivalent)

Who is at highest risk of adrenal crisis?

6

1. Ppt/exacerbate osteoporosis2. Inc. glc3. Water retention4. Abnormal fat deposition5. Ocular effects - glaucoma w/ prolonged use6. Psychiatric - depression, euphoria, mood swings, personality changes

ADRs corticosteroids PO

7

1. Fludrocortisone (Mineralocorticoid)2. Hydrocortisone (Glucocorticoid)

Tx addison's

8

1. Fluid retention (caution in HF)2. Hyperglycemia (caution in DM)3. Pts w/ electrolyte disturbances4. Pts w/ renal impairment 5. Adrenal suppression = immunosuppression

Watch out w/ Fludrocortisone

9

Less

Eczema = more or less of a skin barrier?

10

Increases

Occluding the skin does what to absorption?

11

1. Dec. epidermal barrier function2. Inc. skin fragility3. Poor thermal regulation from dec. sweating4. Inc. surface area to body mass ratio compared to adults

Why do infants have a higher risk of systemic toxicity from topically applied substances?

12

1. Oxidative damage2. Cell senescence3. Amino acid racemization4. Nonenzymatic glycosylation of proteins5. Flattening of the dermal-epidermal junction, dec. cellularity, dec. dermal thickness, loss of vascular & lymphatic beds

Skin aging

13

1. Petrolatum-based vehicles2. Occlusion3. Hydration4. LubricationBest for dry skin - moisture & thick skin

Characteristics of ointments

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1. Faster release of drug2. Little residue left behind

Characteristics of gels

15

1. Absorb moisture2. Dec. friction3. Poor adherence to skin4. Potential inhalation risk

Characteristics of powders

16

Corticosteroids

What is the most prescribed derm product?

17

1. High activity in skin2. Broken down rapidly systematically Works well w/ thin skin, inc. absorption w/ hydration & occlusion1. Fluticasone propionate (Cutivate)2. Prednicarbate (Dermatop)

What is good about "soft" glucocorticoids & what are they?

18

C

Corticosteroid risk in pregnancy?

19

1. Dermal atrophy from antiproliferative action2. Acne3. Hypertrichosis4. Pigment changes5. Infection6. Allergy

ADRs corticosteroids topically

20

RetinoidNight - photoinactivated Might inc. Vit D activity in skin

When should you apply Adapalene cream?

21

ex. Adapalene Cream1. Erythema2. Peeling, dryness3. Tightness & burningCYP2D6 - don't use w/ oral antifungals

ADRs Retinoids

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1. Reduce oil production2. Speed up skin cell turnover3. Fight bacterial infections4. Dec. inflammation

Goals of acne Tx?

23

1. Retinoic acid2. Benzoyl peroxide3. Azelaic acid4. Sulfur/sodium sulfacetamide/resorcinol5. Salicylic acid6. Topical abx

Acne Tx Options

24

Stratum corneum/follicular openingsdec. bacteria - can't build resistance

Where does benzoyl peroxide work?

25

1. Leprosy2. Pemphigus vulgaris3. PCP for acne - Aczone

What do you use Dapsone for?

26

NO

Are topical abx needed for minor surgery?

27

1. Mafenide - inc. risk for candida2. Silver sulfadiazine

What abx do you use for Tx of burns?

28

1. Bacitracin2. Polymixin B3. Neomycin

What drugs are in Neosporin?

29

Disrupt fungal wall synthesis - fungistatic Some antiflammatory activity Good penetration of stratum corneum

How do imidazoles work?

30

AntifungalInterrupts active membrane transport of essential cellular precursorsAntiinflammatory & antibacterial

How does Ciclopirox work?

31

Immunomodulator - ProtopicShort-term, Kids >2

What is used as second line therapy for atopic dermatitis?

32

Immunomodulator 1. IC2. Netherton syndrome3. Active bacterial/viral infection4. Undergoing phototherapyRisk of lymphoma

DO NOT use protopic if...

33

Flushing w/ alcohol ingestionProtopic - Immunomodulator

Which drug in this group has a disulfiram-like rxn?

34

1. CV health2. Colon3. Immunity4. Brain-building5. Skin6. Dec. diabetes7. Laxative

Flaxseed

35

helps lipid panelanticoagulant, heartburn

Garlic

36

BPH

Saw palmetto

37

Antioxidant1. CV2. Immune system3. Anti-cancer

Cranberry

38

menopause

Black cohash

39

immune system

Echinacea

40

1. Antimicrobial, antiinflammatory, vasodilation, antioxidant2. Inc. cerebral circ.3. Dec. HA, dizziness, short-term memory lossInc. bleeding risk

Ginko balboa

41

CA preventionHeavy metal detox

Wheat/barley grass

42

Topical - woundsOral - laxative, DM, asthma, seizures, arthritis

Aloe vera

43

Antiseptic, antibacterialRelieves IBS SzTx Hidradenitis SuppuraativaAnti venom for King cobras

Tumeric

44

Anemia, atherosclerosis, depression, diabetes, edma, HTN, ulcers

Ginseng

45

1. Garlic2. Feverfew3. Ginko4. Ginseng5. Ginger

Herbals to watch w/ anticoagulants?