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1

(Type II Hypersensitivity)

1. IgG (IgM) antibodies attack what? Cause what?

2. Does sensitization of the immune system need to occur to produce IgG antibodies?

1. foreign antigen associated with cells (often RBC); their destruction by phagocytosis or lysis

2. yes (T cells mingling with B cells)

2

1-3. What are three ways that RBC can become foreign antigens?

1. transfusion reaction

2. drug allergies

3. hemolytic disease of the newborn

3

(Ways RBC can become foreign antigens)

(Transfusion reaction)

1. Anitbodies bind to what?

2. then what happens?

3. These antibodies can also activate what? do what?

4. 1st transfusion problem in dogs? 2nd? how bout 1st in cats and humans? why?

1. non-self, blood group antigens (eg A, B, AB, O)

2. macrophages and neutrophils have FcyRI and eath the RBC

3. complement; poke holes in RBC

4. nope; yep; yep (it is a problem); immune system gets shown to carb structures on microorganisms that are similar to RBC carbs (natural antibodies)

4

(Ways RBC can become foreign antigens)

(Drug allergies)

1. Some drugs, such as what? bind to the surface of what? What causes RBC destruction?

1. penicillin; cells (RBC); anti-drug antibodies cause RBC destruction

5

(Ways RBC can become foreign antigens)

(Hemolytic Disease of the Newborns)

1. RBC antigens ot eh fetus stimulate what? Resulting in what?

1. antibody production in the mother; destruction of RBC in the fetus or newborn

6

(Clinical Manifestations of Type II)

1. Intravascular hemolysis of RBC may result in what five things?

2. Are reactions more or less severe upon repeated occurences?

3. How quickly can they occur? as quick as type 1?

1. fever, chills, nausea, clotting within blood vessels, and hemoglobin in the urine

2. more severe (eg repeated blood transfusion)

3. pretty quickly (within 1 or 2 hours); not as quick

7

1. What's the name of the test where your testing to see if antibodies are binding to RBC?

2. What are the two variants?

(just read this slide)

1. the coomb's test

2. direct and indirect

8

B