Dyslipidemia Drugs (M2)

Question 1

What is elevation in any lipoprotein called?

Answer 1

hyperlipoproteinemia or hyperlipidemia

Question 2

What is increased levels of triglycerides called?

Answer 2

hyperlipemia

Question 3

What are the major clinical problems associated with hyperlipidemia?

Answer 3

1. acute pancreatitis

2. atherosclerosis

Question 4

What are foam cells in atherosclerotic plaques made of?

Answer 4

transformed macrophages

Question 5

What are the roles of High-density Lipoproteins (HDL)?

Answer 5

1. retrieve cholesterol from artery wall (from cells and macrophages) and bring to liver
2. inhibit oxidation of atherogenic lipoproteins

Question 6

What are some of the impacts that smoking has, making coronary disease more likely?

Answer 6

1. reduced HDL
2. cytotoxic effects on endothelium
3. increased oxidation of lipoproteins
4. stimulation of thrombogenesis

Question 7

What hydrolyzes chylomicrons to form triglycerides?

Answer 7

lipoprotein lipase (LPL)

Question 8

What is the process of VLDL becoming LDLs and IDLs?

Answer 8

1. accept apoproteins C and E from HDLs
2. export triglycerides to peripheral tissues
3. Hydrolyzed by lipoprotein lipase (LPL)
4. Return apoproteins C and E to HDLs
5. Transformed to LDLs and IDLs

Question 9

What is the function of LDLs?

Answer 9

yield free cholesterol for synthesis of cell membranes

Question 10

What forms Lp(a) Lipoprotein? 1. What is it conected by? 2. Where are these found? 3

Answer 10

1. LDL and the (a) protein
2. disulfide bridge
3. atherosclerotic plaques

Question 11

What secretes HDL?

Answer 11

liver and intestines

Question 12

What does sucrose and fructose raise in the body?

Answer 12

VLDL

Question 13

What does cholesterol and saturated and trans fats increase in the body?

Answer 13

LDL