Drugs Used in Parkinson's (M3)

Question 1

What are the abnormal movements associated with Parkinson’s?

Answer 1

1. tremor
2. chorea
3. athetosis
4. tics

Question 2

What are the parts of the brain that are the most effected by Parkinson’s?

Answer 2

1. cortex
2. thalamus
3. basal ganglia

Question 3

What is the specific area of the brain that is degenerated by Parkinson’s?

Answer 3

pars compacta

Question 4

What is the problems associated with a resting tremor? 1. An intention tremor? 2

Answer 4

1. Parkinson’s

2. lesion of brainstem or cerebellum, drug toxicity

Question 5

What are slow, writhing movements associated with Parkinson’s called?

Answer 5

athatosis

Question 6

What are abnormal postures when sustained called?

Answer 6

dystonia

Question 7

What is the symptom of Parkinson’s that is characterized by shorter steps, difficulty getting out of chair, and feet draging?

Answer 7

bradykinesia

Question 8

What are the five stages of Parkinson’s damage according to the Braak scale?

Answer 8

1. lower brainstem
2. higher brainstem
3. substantia nigra
4. mesocortex and thalamus
5. entire cortex

Question 9

What type of neurons are selectively lost during Parkinson’s?

Answer 9

dopaminergic neurons that normally inhibit GABAergic output

Question 10

What are the other major movement disorders?

Answer 10

1. Huntington’s disease
2. Tics (Gilles de la Tourette’s Syndrome)
3. Tardive Dyskinesia

Question 11

For Huntington’s disease, where is GABA reduced?

Answer 11

basal ganglia

Question 12

For Huntington’s disease, what is specifically reduced?

Answer 12

choline actylthransferase

Question 13

For Huntington’s, what is the chorea a result of?

Answer 13

overactivity in dopaminergic nigrostriatal pathways