NSAIDs (M2)

Question 1

What do the COX-1 and COX-2 pathways directly form? 1. What do these eventually generate? 2

Answer 1

1. PGG2 and PGH2

2. prostaglandins, thromboxane, and prostacyclin

Question 2

What does the LOX pathway directly form? 1. What do these eventually generate? 2

Answer 2

1. HPETEs

2. HETEs and leukotrienes

Question 3

What are the validated combined indices developed for Rheumatoid Arthritis?

Answer 3

1. Disease Activity Index

2. American College or Rheumatology Response Index

Question 4

Which NSAID is the least effective?

Answer 4

aspirin

Question 5

Which NSAID is not effective for gout treatment?

Answer 5

Tolmetin

Question 6

Which NSAID has high BI and renal side effects?

Answer 6

Ketorolac

Question 7

Which NSAID use results in liver function abnormalities?

Answer 7

1. Diclofenac

2. Sulindac

Question 8

Which NSAIDs have the greatest toxicity?

Answer 8

1. indomethacin

2. tolmetin

Question 9

Which NSAIDs have the least toxicity?

Answer 9

1. aspirin
2. salsalate
3. ibuprofen

Question 10

Which NSAIDs are best to use if there is renal insufficiency?

Answer 10

nonacetylated salicylates

Question 11

What is the progression of rheumatoid arthritis?

Answer 11

1. Immune system attacks synovium
2. Inflammation destroys cartilage and bone
3. tendons and ligaments weaken and stretch
4. joint loses its shape

Question 12

What are deposits of crystalline uric acid at the surface of joints, in skin or cartilage, as a feature of gout?

Answer 12

Tophi

Question 13

What are episodes of acute arthritis due to deposits of monosodium urate in joints and cartilage?

Answer 13

gout

Question 14

What are the side effects of gout?

Answer 14

1. uric acid calculi
2. tophi
3. interstitial nephritis