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Review / Wrong Answers > Pathoma - Wound healing > Flashcards

Pathoma - Wound healing Flashcards

1
Q

Examples of labile tissues

A

Stem cells that continuously recycle

e.g. small and large bowel, skin, bone marrow

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2
Q

Examples of stable tissues

A

Cells that are quiescent but can regenerate when necessary

e.g. hepatocytes

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3
Q

Examples of permanent tissues

A

Lack regeneration potential:

(1) Myocardium
(2) Skeletal musle
(3) Neurons

These cells must heal via repair (cannot heal via regeneration)

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4
Q

What are the 3 components of granulation tissue?

A

(1) Fibroblasts
(2) Capillaries
(3) Myofibroblasts

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5
Q

What is the function of fibroblasts

A

Deposition of Type III collagen

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6
Q

What is the collagen transition involved in scar formation

A

Type III collagen replaced with Type I collagen

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7
Q

What enzyme is required to remove type III collagen

A

Collagenase

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8
Q

What is the cofactor for Collagenase

A

zinc

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9
Q

What role does TGF-a play in tissue repair

A

TGF-a is an epithelial and fibroblast growth factor

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10
Q

What role does TGF-B play in tissue repair

A

TGF-b is an important fibroblast growth factor + anti-inflammation

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11
Q

What role does Platelet-derived growth factor (PDGF) play in tissue repair

A

growth factor for endothelium, smooth muscle, and fibroblasts

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12
Q

What role does fibroblast growth factor (FGF) play in tissue repair

A

important for angiogenesis, also mediates skeletal development

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13
Q

What role does vascular endothelial growth factor (VEGF) play in tissue repair

A

important for angiogenesis

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14
Q

What is the function of myofibroblasts

A

Contraction of the wound after it has been filled with granulation tissue

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15
Q

What contains Type I collagen

A

Bone, skin, tendon, fascia, cornea, late wound repair

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16
Q

What disease has decreased collagen type I production

A

Osteogenesis imperfecta

17
Q

What contains Type II collagen

A

Cartilage, vitreous body

Remember: 
1 - strong
2 - slippery
3 - bloody
4  - BMs
18
Q

What contains Type III collagen

A

skin, blood vessels, uterus, granulation tissue

19
Q

What disease has deficient type III collagen

A

Vascular Ehlers-Danlos

20
Q

What contains Type IV collagen

A

Basement membrane

21
Q

What disease has deficient type IV collagen

A

Alport syndrome

22
Q

What is the collagen deficiency in Ehlers-Danlos

A

Type V

23
Q

What is the role of vitamin C in wound repair

A

hydroxylation of proline and lysine pro-collagen residues

24
Q

What is the role of copper in wound repair

A

Copper is a cofactor for lysyl oxidase, which cross-links lysine and hydroxylysine to form stable collagen

25
Q

What is the role of zinc in wound repair

A

Cofactor for collagenase, which is needed to replace Type III collagen with Type I

26
Q

What collagen is in excess in keloids

A

Type III

Review / Wrong Answers (140 decks)

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