A: 25-28

Question 1

Benzo’s MOA

Answer 1

Increase affinity of endogenous GABA to GABA-R

Increase frequency of Cl- Ch. opening

Question 2

Benzos and DOA

Answer 2

super MaN is super fast
DC movies are super long
A is in the middle of mAn
Midazolam, Nitrazepam
Alprazolam
Diazepam, Clonazepam

Question 3

Diazepam indicationns

Answer 3

Anesthetic
Sedation
Muscle relaxant
Panic
Withdrawal

Question 4

Clonazepam indic.

Answer 4

Bipolar

Seizures

Question 5

Benzo’s drug interaction

Answer 5

Antihistamines gen 1
Alcohol
Barb’s
…

Question 6

Benzo’s antag.

Answer 6

Flumazenil

Question 7

Non Benzo’s

Answer 7

Zaleplon, Zolpidem- GABA-A agonist

Your BMR is up when you sleep well

Busiprone- 5HT partial agonist. Busi is prone to allergies
Melatonin-
Rameltone- Melatonine agonist. ram sleeps and dream on Elton

Question 8

1st gene antipsych. and SE

Also MOA

Answer 8

CHF is a chronic old Disease (CHFD)

Chlorpromazine- low potency! Corneal deposits
Haloperidol- Neuroleptic malignant Synd.
Droperidol
Flupentixol- wheb you have FLU you PENT IX on ALL

Promise me there is no Chlor!
Halo! Drop to the Floor

All block D2-R

Question 9

1st gene antipsych. SE

Answer 9

Tardive dyskinesia
Hyperprolactinemia
Weight gain
Autonomic
Thermo

Question 10

Primary indication for antipsych.

Answer 10

Schizofrenia

Question 11

1st gene antipsych. are for positive or negative symp?

Answer 11

Positive

Question 12

2nd gene antipsych.

Answer 12

Quiet pls! Only Whispering is Appropriate

Quetiapine and Clozapine. CLOZAP! Quit tipping
Olnazapine- CLOZ the door with your OLNA
Risperidone- RiIS got married to mathew PERI and now they are DONE
Aripiprazole- ARI PIPed to RAZ

**Cariprazine

Question 13

2nd gene antipsych. dominant MOA

Answer 13

5-HT blockade

Question 14

Benzo’s indication

Answer 14

Status epilepticus
Psychosis
Sleep problems

Not for major depression

Question 15

Antagonism for Benzo’s

Answer 15

Flumazenil

Question 16

Depot injection

Answer 16

Injection formulation of a medication which releases slowly over time

Question 17

Antipsychotics antag D2-R MOA

Answer 17

D2-R are Gi coupled
So if we inhibit –> Increased cAMP (Bcs usually if Gi is active the cAMP will decrease)
Increased cAMP cases NF on the Dopamine release

Question 18

D2-R are where?

Answer 18

Mesolimbic system

Striatal Frontal System

Question 19

1st gene Antipsych. SE

Answer 19

Extra Pyramidal
ADAPT
Acute Dystonia, Acathesia, Parkinsonism, Tyrid diskinesia