B: 29-31

Question 1

Cytotoxic agents and MOA

Answer 1

Cyclophosphamide- Alklyting. Adds on Guanine N7
Methotrexate- Inhib. Folate
Azathioprine- –> 6MP inhibits purine synt.
Mycophenolic acid- Inhibits GTP synt.
Leflunomide- inhibits pyrimidine synt.

CAMML- גמלים יש מפרקים כאלו מוזרים כמו ראומטויד ארטרייטיס שצריך לטפל בזה עם חומרים סיטוטוקסיים

Question 2

Cyclophosphamide SE and how to prevent

Answer 2

Hemorrhagic cyctitis

Give Mesna

Question 3

Which drug intrferes with Azathioprine metab.?

Answer 3

Allopurinol

Question 4

Inhib. of Cytokine gene expression and MOA

Answer 4

Cyclosporine- inhib. Calcineurin. Decrease IL2/3..
Tacrolimus- inhib. Calcineurin. FK506. taKKrolimus
Sirolimus- mTOR inhib. Stent!! mTOR is important SIR
Tofacitinib- JAK inhib. JAK took all the tofi!

i eat in a Cycle Taco and Tofi in a Sir

Question 5

Tofacitinib indications

Answer 5

Autoimmune

בגלל שג’ק אכל את כל הטופי נהייתה לו מחלה אוטואימיונית

Question 6

5 ASA derivative for autoimmune disease and MOA

Indication

Answer 6

Sulfasalazine
PPAR agonist to reduce cytokines and COX inhib.
Reduce NFKb
For autoimmune
For IBD (UC>>CD)

Question 7

Cyclosporine and Tacrolimus inhibit

Answer 7

Calcineurin

Normally activates T cells

Question 8

Cyclosporine and Tacrolimus SE

Answer 8

Nephrotoxicity

Question 9

Immunotherapy- Fusion and Ab and MOA

Answer 9

Rituximab- anti CD20. reduce B. Ritux reduce B
Infliximab, Adalimumab- Anti TNFa
Toclizumab- Anti IL6. T+B
Ustekinumab- Anti IL12. inhib TH1 אוזבקים צריכים עזרה
Natalizumab- Inhibit T cell anti integrin נטטטלי
Dupilumab- Anti IL4 די זה האות הרביעית
Abatacept- Fusion protein inhib. CD28 on T cell. אבא תצא! הפיוזון הזה לא טוב לך. אבטצפת הכי לא קשור

ximab is chimeric
umab is fully human
zumab is huminized

Question 10

Immunotherapy- Fusion and Ab and common SE

Answer 10

Injection side reaction

Infections

Question 11

Immunotherapy- Fusion and Ab and indication

Answer 11

Rituximab- B cell lymphoma, autoimmune
Infliximab, Adalimumab- autoimmune
Toclizumab- RA
Ustekinumab- Chron's
Natalizumab- MS
Dupilumab- Atopic DDDermatitis
Abatacept- RA

Question 12

Anti Thymocyte Globulin

Answer 12

For stem cell Transp.
Prevent G VS H disease
For solid organ Transp.