A: 5-11

Question 1

Local anasthetics classifications

Answer 1

Amides: Lidocaine, Articaine, Bupivacaine
לידוקאין זה ברור. ללקק ארטיק עם הבובי שלך כמו לוקל
Ester: Cocaine

All metab. by CYP450

Question 2

Drug with the fastest onset of action local anasth.

Answer 2

Articaine

אתה אוכל ארטיק וישר זה מקפיא לך את המח

Question 3

Long acting local anasth.

Answer 3

Bupivacaine

CNS toxicity!

Question 4

Cocaine metabolism

Answer 4

By Pseudocholinestrase

Question 5

Excesp cocaine, all local anasthetics are

Answer 5

Vasodilators

Question 6

Glucocorticoids for parenteral and oral use

Answer 6

Hydrocortisone- short. Replacement of cortisol
Prednisolone- Systemic anti inflammatory
Methylprednisolone- Systemic anti inflammatory
Dexamethasone- Diagnosis ACTH. Asthma
Triamcinolone- Topical

Question 7

Mineralocorticoids

Answer 7

Fludrocortisone

Flud like fluid

Metyrapone- Blocks Cortisol synthesis. Diagnosis of Adrenal insuf.
מתיר לנו לבדוק

Question 8

Topical glucocorticosteroids

Answer 8

Fluocinolone
Budesonide
Momethasone
Fluticasone

Best Friends For Me

Question 9

Androgens

Answer 9

Testosterone undecanoate (Causes Virilization in female)
Nandrolone is anabolic steroid

Question 10

Anti androgens

Answer 10

Bicalutamide for prostate cancer

Question 11

5a reductase inhibitor

Answer 11

Finasteride for male baldness
BPH

Like thin- thinning hair
finA- a reductase

Question 12

GnRH drugs

Answer 12

Goserelin- GO GO GO! agonist! Prostate cancer

Degarelix- antagonist. For prostate cancer

Question 13

Sildenafil indications

Answer 13

PDE5 inhib!

BPH
Pulmonary HTN
Erectile

Question 14

Estrogens

Answer 14

Ethinylestradiol

Question 15

Anti estrogens

Answer 15

Tamoxifen- breast cancer
Raloxifen- osteoporosis
Clomifen- ovulation induction.
Tmai Relax! אין לך כלום

Antagonist on breast CNS uterus
Agonist on bone and liver

Question 16

Aromatase inhibitor

Answer 16

Anastrozol

אנס את הארומטייז

Question 17

Anti PLT

Answer 17

Aspirin- Reduce TXA2 production
Clopidogre, Ticagrelor, Prasogrel- ADP-R antag.
Abciximab- IgG against GPIIb/IIIa

Question 18

Dual anti PLT

Answer 18

Aspirin + Clopidogrel

Question 19

ADP-R antag.

Answer 19

Clopidogrel and Prasogrel are pro drug. activated by CYP450
Ticagrelor is already active

למי שיש טיקה על המצח הצ’אקרות שלה כבר פתוחות

Question 20

Contraceptive- MOA

Answer 20

Ethynyl-estradiol/Levonogestrel-
Levonogestrel
Medroxy-progesteron-acetate
Desogestrel

Prevent LH surge

Question 21

Combination agents are divided into

Answer 21

Monophasic- same dose of both components
Biphasic- changes twice a cycle
Triphasic- “ three times “

Question 22

Morning after pill

Answer 22

High dose Progesteron

Levonogestrel

Question 23

Medroxy-progesteron-acetate

Answer 23

long-acting progestogen-only injectable contraceptive
treat and prevent menopausal symptoms

3 months duration for the injection

Question 24

Elevated EC Ca and local anasthetics

Answer 24

Partially antagonizes

Question 25

Elevated EC K+ and local anasthetics

Answer 25

Enhanced effect of local anasthetics

Question 26

How do local anasthetics block VGNaCh?

Answer 26

Non ionized form crosses the memb

Ionized form blocks the channel from within