C: 8-13

Question 1

Chloramphenicol
Polymixins
Antifolate

Answer 1

Chloramphenicol is a big long word. Big like 50S
Inhibit Peptydil transferase
Grey baby
אם תשפוך כלור על תינוק הוא יהפך לאפור
For meningitis
Antifolate:
Sulfametoxazole inhib Dihydro synthase. Sulga drug, G6PD, nephro
Trimethoprin inhib Dihydro reductase. Bone marrow supp.
Proguanil
Colistin

Question 2

Colistin

Answer 2

Cationic
Distarbe the membrane
Inactivates endotoxins

Give topical due to severe toxicity

Question 3

Aminoglycosides

Answer 3

GANT? yeS! קניתי

Gentamycin
Amikacin
Tobramycin
Netilmycin
Strpto
Neomycin
Kanamycin

For aerobic G- like E.coli
Commonly given with B lactam
Ototoxicity, Nephro., teratogenic

Question 4

Neomycin

Kanamycin

Answer 4

Suppress intetinal flore before bowel surgery

Neomycin topical

Question 5

Monobactem

Answer 5

Aztreonam
Only G-
Pseudomonas

Question 6

Imipenem/Meropenem

Which genereation?

Answer 6

2nd

Question 7

Give imipenem with

Answer 7

Cilastatin to inhibit nephrotoxicity

Question 8

Imipenem/Meropenem

When to give

Answer 8

Hospital aquired
Pneumonia
Sepsis

Question 9

Imipenem/Meropenem

Special SE

Answer 9

Seizures due to inhibition of GABA-R

Question 10

Give Tzobactam with

Answer 10

Piperacillin

Question 11

Give Meropeneme with

Answer 11

Vaborbactam

Question 12

Community aquired pneumonia Tx.

Answer 12

Clarithromycin

Azithro

Question 13

ICU pneumonia Tx.

Answer 13

B lactam IV + Macrolides/Fluoro-

Question 14

B lactam AB resistant to B lactamase

Answer 14

Carbapenems

BUT! bacteria can have Carbapenemase (MBL)

Question 15

Chloramphenicol MOA

Answer 15

S50

Inhibits Peptydil transferase

Question 16

Chloramphenicol indication

Answer 16

Empiric for meningitis

Question 17

Chloramphenicol SE

Answer 17

Grey baby syndrome
Bone marrow
Aplastic anemia

Question 18

Polymixin

Answer 18

Colistin
Cell wall
Inactivate endotoxins
Topical
Neuro and nephro-toxic

Question 19

Antifolate drugs

Answer 19

Sulfamethoxazole- DH Synthase
Trimethoprim- DH Reductase
Proguanil-

Question 20

Sulfamethoxazole
Trimethoprim

Indications

Answer 20

TMP-SMX
MRSA
Pneumocystis
UTI empiric
MRSA
Nocardia

Question 21

Sulfamethoxazole MOA

Answer 21

Compete with PABA

Question 22

Sulfamethoxazole
Trimethoprim

SE

Answer 22

Sulfamethoxazole- Sulfa, bone marrow, G6PD, nephro, terat, SJS
Trimethoprim- Bone marrow

Question 23

Glycicycline

Answer 23

Tigecycline

Question 24

Tigecycline

All

Answer 24

MRSA
VRE
IV! excreted in bile

Enamel, bone growth
Hepatotoxiciy
Neprho
Photosens
Vestibular toxicity

Question 25

Doxyxycline indications

Answer 25

``` Community aq pneumonia Gonorrhea Tick born Zoonotic Acne ```

Question 26

Doxyxycline elimination

Answer 26

Fecally

Question 27

Aminglycosides

Answer 27

``` GANTS is in the army Gentamycin Amikacin (אני קצין) Netilmycin Tobramycin (cobra sign) ``` Streptomycin Neomycin Kanamycin

Question 28

Gentamycin Amikacin (אני קצין) Netilmycin Tobramycin (cobra sign)

Answer 28

Aerobic G-

Question 29

Which AB are time dependant?

Answer 29

Penicillin | Cephalosporins

Question 30

Which AB are concentration dependant?

Answer 30

Aminglycosides

Question 31

What does concentration dependant mean?

Answer 31

Antibacterial effect increases prop above the MIC

Question 32

Streptomycin

Answer 32

TB Tuleramia Plague

Question 33

Neomycin | Kanamycin

Answer 33

Suppress intestinal flora before bowel surgery | Neomycin for topical use

Question 34

Aminglycosides SE

Answer 34

``` Ototoxicity Nephro Neuromascular blockade Allergy Teratogenic ```

Question 35

How to remember Aminglycosides are teratogenic?

Answer 35

צבא זה לא משחק ילדים חיילים צריכים הרבה אמינו אסידס