C: 5-7 Flashcards
1
Q
HSV,CMV,VZV,H.Flu
A
Acyclovir Valcyclovir is prodrug of Gancyclovir Gancyclovir can cause bone marrow suppression Cidofovir- inhib. viral DNA pol. HSV! Foscarnet- same. 2nd line CMV Oseltamivir Palivizumab Ribavirin
2
Q
Acyclovir MOA
A
Monophosph. by viral Thymidine Kinase
Incorp into DNA
Lack 3’ -OH
3
Q
Gancyclovir MOA
A
UL96 Kinase
CMV!
4
Q
Cidofovir MOA
SE
A
Cytidine analog
Nephrotoxic- give with probenecid
5
Q
Antiretroviral
A
NRTI's: Ziduvodine Lamivudine- Least potent, Also for Hep. B Emtricitabine Abacavir- Guanosine analog Tenofovir- nucleotide. Also for Hep C
NNRTI’s:
Etravirine. אתרע מזלו
6
Q
Resistamce to NRTI
A
Mutation to pol gene
7
Q
Which NRTI can cause Fanconi’s syndrome?
A
Tenofovir
8
Q
Protease inhib.
A
Ritonavie
Darunavir
Lopinavir
ריטה דרה בלופט
9
Q
Which drug can inhibit CYP450?
A
Ritonavir
ריטה גדולה מהחיים
10
Q
Integrase inhib
Fusion inhib
A
Elvitegravir
Maraviroc
11
Q
Ribavirin SE
A
Hemolytic anemia
12
Q
Agents against hepatitis
A
INF-a- JAK STAT. Flu like symp.
Entecavir inhibits DNA pol
Tenofovir is nucleotide analog
Direct acting antivirals: Paritaprevir Grazoprevir Sofosbuvir Dasabuvir Velpatasvir Elbasvir
