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Pharma final > A: 29-33 > Flashcards

A: 29-33 Flashcards

1
Q

Tricyclic
Tetracyclic
Unicyclic
MAO-inhib

A 
Tricyclic- Amitriptyline, Clomipramine. Ami tripped the line, כלום לא ישנה את הפרייד שלי
Tetracyclic- Maprotiline. מה פרו? טיל!
Unicyclic- Bupropion. Bu!prop!yon!
MAO-inhib- Maclobemide MAoclobemide
AC-M-B-M-T
CAM Be with Me
Trazodone is a 5HT inhibitor
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2
Q

Maprotiline MOA

A

NET»SERT

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3
Q

Tricyclic MOA

A

Like SNRI

Inhibit NET and SERT

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4
Q

Tricyclic SE are due to

A

Muscarinic, a1, H1 blockade

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5
Q

SSRI’s

A

Work in the brain so CSF!
Sir. Tralin! the Chita-lo-pram has Flu so EXIT!

Sertraline
Citalopram
Fluoxetine

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6
Q

SSRI’s indication

A 
Major depressive disorder
Anxiety
OCD
PTSD
Panic
Bolemia
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7
Q

SSRI’s metabolism

A

Inhibitors of CYP450

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8
Q

SNRTI’s

A

בוא נלך לאכול בוואן לאפה ונשתה רבוקס דלוקס

Venlafexine
Reboxetine (Only NET)
Duloxetine

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9
Q

NE-R antag. for antidepression

A

Mitrazapine is an a2 antagonist

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10
Q

5-HT 2/3 antag. for antidepression

A

Agomelatine is also agonist at MT1/2

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11
Q

Lithium SE

A 
Reversible hypothyroidism
DI bcs Li+ antag ADH-R
GI
Tremor
Ataxia
Nephrogenic DI
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12
Q

Valproate MOA

A

blockade of voltage-gated sodium channels and increased brain levels of GABA for the Tx. of the manic phase

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13
Q

Carbamazapine MOA

A

Extends the inactivated phase of Na+ Ch. on the axon so no AP

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14
Q

Anti epileptic which are not broad spectrum

A

Phenytoin- Inhib. of axonal NaCh
Carbamazapine- -“-
Vigabatrin- Inhibits GABA metab.
Phenobarbital- GABA NaCh open longer

Very Privet Cards Play
Privet bcs it is narrow spectrum

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15
Q

Broad spectrum antiepileptics

A

Ethusoximide- inhibits Thalamic Ca2+ Ch. Alot of Ethous to work on the Thelamic
Lamotrigine- Inhibits Na axonal channels. למה לא?TRIGGED?
Levetiracetam- Block Glutamate release. לב לתירצה סתם
Valproate- inhibits Thalamic Ca2+ Ch
Clonazepam- GABA-A
Diazepam- GABA-A

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Pharma final (24 decks)

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