B: 32-37

Question 1

Antimetabolites

Answer 1

5 Fluorouracil- Inhib. Thymedilate synthase
Methotrexate- Anti Folate
6-Mercaptopurine- Anti Purine
Cytarabine- Anti Pyrimidine. Rabin is very old like from the pyramides ages
Capecitabine- into 5FU. Caphe they are the sons of hay nam! like capecitabin is the son of 5FU
Pemetrexed- Anti Folate. Pem did many Trix with Jym

Question 2

Which drug reduces the toxic effect of Methotrexate?

Answer 2

Leucovorin= folinic acid

Question 3

Fluorouracil indic.

Answer 3

Colon cancer
Breast Head and neck
BCC topical

Question 4

Methotrexate special SE

Answer 4

Pulmonary fibrosis

Question 5

6MP indic

Answer 5

CML

ALL

Question 6

Alklyting agents

Answer 6

Cyclophosphamide- Add on Guanine N7
Cisplatin- cross links two strands with platinum
Oxaliplatin- for colon cancer
Dacarbazine- needs CYP450
Temozolomide- for Glioblastoma!
Bleomycin- free radicals
Actinomycin D- RNA pol. for childs tumor

DOCTor!!! ABC!!!

Question 7

Which is for CNS tumors?

Answer 7

Temozolomide

Question 8

Cisplatin SE

Answer 8

Oto

Nephro

Question 9

Give Cyclophosphamide with

Answer 9

Mesna to protect the bladder

Question 10

Cyclophosphamide SE

Answer 10

SIADH

HC

Question 11

Topoisomerase inhib.

Answer 11

Etoposide- Topo 2
Irinotecan- Topo 1
Doxorubicin- Topo 2 CCNS

Topo inhibitors make DNA DIE!

Question 12

Doxorubicin indications

Answer 12

Breast cancer

ציצי זה כמו שני אבני רובי וגם זה בא בזוג כמו טופיאייזומרייס 2

Question 13

Microtubule inhib.

Answer 13

Vincristine- inhibit. polym. ALL. Cristine is unstable
Docetaxel- enhance polym. Breast Lung Overian. DOCtors who pay TAXes stabilize the economy

VIN and CRISTINE went to the DOC to pay TAX

Question 14

Hormonal agents

Answer 14

Prednisolone for ALL and Lymphomas
Tamoxifen- SERM. breast cancer
Anastrazole- aromatase inhib.
Goserelin- GnRH inhibits LH/FSH due to desens.
Degarelix- GnRH antagonis for prostate cancer
Bicalutamibe- prostate. Bi for 2 testicles
Octreotide- Somatostatin analog

DOG or BAT?

Question 15

Small molecule signal transduction inhib.

Answer 15

Imatinib- TK inhib. BCR-ABL for CML. C-kit אמא יש לי סיאמאל
Gefitinib, Erlotinib- EGFR antag. NSCLC ג’ף וארי זה שני מעשנים כרוניים עם סרטן ריאה
Lapatinib- TK inhib. HER2 Lap of breast like lack of breast
Sunitinib- TK inhib. סונים
Ibrutinib- TK inhib like hebrew
Crizotinib- ALK inhib. Cris speaks Hebrew
Bortezomib for MM
Dabrafenib(BRAF)+Trametinib for Melanoma Dabra is on the tram and there is a lot of sun
Everolimus- mTOR inhib for renal cancer. renal cancer and mTOR for EVER
Tretinoin- AML and Acne. All trans retinoic acid

Question 16

Large molecule signal transduction inhib.

Answer 16

1. Trastuzumab- Anti HER2 trust me i cure breast cancer. but cardiotoxic
2. Panitumumab- anti EGFR. colon. Eating panir
3. Rituximab- Anti CD20. CLL, Hodgkins
4. Bevacizumab- Anti VEGF for colon. colon be evacuated from cancer
5. INF-a for CLL, T cell lymphoma
6. Aldesleukin stimulates T cells for renal cancer. Aldes like aldostrom which works in renal
7. Pembrolizumab is activates T cell for melanoma. pembrol sounds like a pimple that rolls on your skin

TiP! dont go to RIBA Pal

Question 17

RA Tx.

Answer 17

Rituximab with Methotrexate

Question 18

Trastuzumab SE

Answer 18

Cardiotoxicity

Question 19

Rituximab SE

Answer 19

50% of patients will have injection site reaction
Serum sickness
HSN III