B: 13-19 Flashcards
Drugs for peripheral vascular disease
Cilostazol- PDE3 inhib. for claudication
Pentoxyfylline- reduce blood viscocity
Vinpocetine- inhib. of Ca and Na Ch
Nicergoline- a1 antag. decrease PLT aggregation
Calcium-dobesilate- reduce PLT aggregation. for diabetic retinopathy
Nicergoline is an ___ derivative
Ergot
Therapy fot migrane
Sumatriptan- 5HT1B/D agonist. first line of Tx. Prophylaxis: Galcanezumab Cinnarizine- CCB Propranolol Verapamil- CCB Carbamazapine- inhib. VGNaCh Valproate- somrthing with GABA Imipramine- inhibits. 5HT and NE reuptake
Drugs for acute HF
Diuretics Dobutamine Milrinone Nitrates Morphine
What is contraindicates in acute HF?
B blockers
Positive ionotropes
Digoxin inhibitis Na/K ATPase so I.C Ca increases
Digitoxin
Dobutamine for acute HF
Milrinone- PDE inhib. for Acute HF
Levosimendan- Ca sensitizing agent. also causes vasodilation
Digoxin more MOA
Reduces AV conduction
Negative dromotropic effect
affects the conduction speed (in fact the magnitude of delay) in the AV node, and subsequently the rate of electrical impulses in the heart
Adenosine actions
A1- Gi-R. hyperpolarization
A2- Gs-R. Vasodialtion
For AV nodal errhythmias
Antag. with Theophyline
Hypertension: CCB and other Vasodilators
Nifedipine
Nimodipine
Amlodipine
Felodipine
Bosentan- Endothelin antagonist. For pulmonary HTN
Hydralazine- NO releasing. NO increases cGMP
Sildenafil- PDE5 inhib.
Drugs used in HTN
Diuretics- Thiazides, Loops
Sympatholytics- Clonidine, Methyldopa
Vasodilators- CCB, NO…
ACEi
Rami captore Enala and Perindo
Ramipril
Captopril
Perindopril
Enalapril
ARB’s
Val and Lo! כן ירבו
Valsartan
Losartan
Irbesartan
Neprisyline inhib.
Sacubitril
Sacubitril+valsartan
Sacubitril+valsartan=
Entresto
For resistanat CHF
