Flashcards in Acetaminophen Deck (11)
What is the MOA of acetaminophen?
Central anti-prostaglandin effect (very LITTLE peripheral nerve activity):
-pain reduced via blockade of: NMDA receptor activation in CNS; AND Substance P in the SC!
What is the class of acetaminophen?
What does Acetaminophen LACK, which is why it is NOT a true NSAID? This makes it a good choice for?
lacks peripheral activity- weak anti-inflammatory action
Good choice for :
-Pts who need well fxning platelets
Tell me about the potency of acetaminophen w/r/t ASA
Similar potency as ASA (in single analgesic doses, has same time-effect curve)
What is the dose of acetaminophen?
325-650mg Q4-6 hours
Howis acetaminophen metabolized?
conjugated and hydroxylated to inactive metabolites; very little excreted unchanged by the kidneys
What is the IV dose of acetaminophen?
1000mg IV (or 1gram) over 15min Q4-6 hours
What is the max dose IV of acetaminophen?
4 grams! can get liver and kidney damage
What is a major side effect of acetaminophen and renal?
-renal papillary accumulation of metabolites can cause renal cell necrosis
-may be a development of ESRD
-but NSAIDS are higher risk of renal tox!
What can overdose of acetaminophen cause?
serious or fatal HEPATIC INJURY
-liver can only metabolize a limited amt of the hapatotoxic metabolite N-acetyl-p-benzoquinone with Glutathione
-when glutathione outnumbered by OD of acetaminophen hepatic injury occurs
-safe dose EVEN LOWER in ETOH
-increased tox with Isoniazid