Flashcards in Phenobarbital Deck (14)
What is the class of Phenobarbital?
What is Phenobarb used for?
to treat insomnia and preop for sedative effects;
anticonvulsant for acute trtment of partial seizures and tonic-clonic seizures
What is the MOA of Phenobarb?
-increases influx of Cl- hyperpolarizing the membrane
-depresses the sensory cortex, causes drowsiness/sedation, decreases motor activity
How is phenobarb metabolized?
CYP450 inducer and metabolized in liver by hydroxylation and glucuronide conjugation. also excreted unchanged in the urine as high as 60%-90%!!
What is the e 1/2 l for phenobarb?
What is the onset for PO? IV? for phenobarb
20-60 min onset PO
5 min IV
What is the DOA of phenobarb? PO? IV?
po 6-10 hours
IS phenobarb protein bound?
weakly to moderately PB 20-40%
What are side effects of Phenobarb?
What are the contraindications to phenobarb?
-Hypersensitivity to barbs
-severe liver disease
What are drug interactions with Phenobarb?
they are enzyme inducers! increased metabolism of:
What are CYP2C19 inducers that would decrease the levels of effectiveness of Phenobarb?
What is the pre-op sedation dose of phenobarb?
IM 100-200mg 1-1.5hrs before the procedure