Flashcards in Remifentanil Deck (23)
What is the trade name of Remifentanil?
What is the formal drug class of Remifentanil?
synthetic mu-opioid agonist
piperidine-derived with an ester link
What is different about the metabolism of Remifentanil?
-ester linkage and the resultant ultra- rapid metabolism of this drug make it unique among the opioids
What are the uses of Remifentanil?
-analgesic during GA, in which quick onset and offset of effect is desired
-used for suppression of transient sympathetic nervous system response to direct laryngoscopy and tracheal intubation
How is Remifentanil metabolized?
-undergoes rapid metabolism by nonspecific plasma and tissue esterases
-metabolized to inactive metabolites excreted by the kidneys
Is Remifentanil metabolized by pseudocholinesterases?
NO; therefore clearance is not affected by cholinesterase deficiency
What is the onset of action of Remifentanil?
1 - 3 minutes
When is the peak of Remifentanil?
1.5 - 2 minutes
What is the DOA of Remifentanil?
7 - 12 minutes
What is the elimination 1/2 life of Remifentanil?
What is the clearance of Remifentanil?
3 - 5 L/min
What is the Vd?
0.3 - 0.5 L/kg ~25mL in adults
Is Remifentanil protein bound?
What is the induction infusion dosage of Remifentanil?
0.5 - 1 mcg/kg over 60-90 seconds
What is the addnal bolus dose of Remifentanil?
0.1 - 1 mcg/kg
What is the maintenacne infusion rate of Remifentanil?
0.1 -1 mcg/kg/min
What is the loading dose of Remifentanil?
1 -2 mcg/kg
What is the dose of Remifentanil?
1 -2 mcg/kg
What is the Infusion rate of Remi?
0.05 - 0.25 mcg/kg/min
What is unique about Remifentanil?
chemically r/t fentanyl but has ester linkage
What is unique about Remifentanil's Vd?
VERY SMALL Vd, minimal accumulation in tissues, even with infusion
What is the potency of Remifentanil similar to?
Potency similar to fentanyl; 100 times more potent than morphine