Flashcards in Remifentanil Deck (23):
1
What is the trade name of Remifentanil?
Ultiva
2
What is the formal drug class of Remifentanil?
synthetic mu-opioid agonist
piperidine-derived with an ester link
3
What is different about the metabolism of Remifentanil?
-ester linkage and the resultant ultra- rapid metabolism of this drug make it unique among the opioids
4
What are the uses of Remifentanil?
-analgesic during GA, in which quick onset and offset of effect is desired
-used for suppression of transient sympathetic nervous system response to direct laryngoscopy and tracheal intubation
5
How is Remifentanil metabolized?
-undergoes rapid metabolism by nonspecific plasma and tissue esterases
-metabolized to inactive metabolites excreted by the kidneys
6
Is Remifentanil metabolized by pseudocholinesterases?
NO; therefore clearance is not affected by cholinesterase deficiency
7
What is the onset of action of Remifentanil?
1 - 3 minutes
8
When is the peak of Remifentanil?
1.5 - 2 minutes
9
What is the DOA of Remifentanil?
7 - 12 minutes
10
What is the elimination 1/2 life of Remifentanil?
10 minutes
11
What is the clearance of Remifentanil?
3 - 5 L/min
12
What is the Vd?
0.3 - 0.5 L/kg ~25mL in adults
13
Is Remifentanil protein bound?
66-93%
14
What is the induction infusion dosage of Remifentanil?
0.5 - 1 mcg/kg over 60-90 seconds
15
What is the addnal bolus dose of Remifentanil?
0.1 - 1 mcg/kg
16
What is the maintenacne infusion rate of Remifentanil?
0.1 -1 mcg/kg/min
17
What is the loading dose of Remifentanil?
1 -2 mcg/kg
18
What is the dose of Remifentanil?
1 -2 mcg/kg
19
What is the Infusion rate of Remi?
0.05 - 0.25 mcg/kg/min
20
What is unique about Remifentanil?
chemically r/t fentanyl but has ester linkage
21
What is unique about Remifentanil's Vd?
VERY SMALL Vd, minimal accumulation in tissues, even with infusion
22
What is the potency of Remifentanil similar to?
Potency similar to fentanyl; 100 times more potent than morphine
23