Flashcards in Isoproterenol Deck (12)
What is the trade name of Isoproterenol?
What is the drug classification of Isoproterenol?
Synthetic catecholamine, selective for beta adrenergic receptors
What are the primary uses of Isoproterenol?
-chronotropic agent for heart transplant
-"chemical pacemaker" for heart block and bradydysrhythmias
-mild pulmonary vasodilating effects (reduce PulmVR)
What is the MOA of Isoproterenol?
Provides non-selective beta-adrenergic stimulation of Beta 1 > Beta 2
-also a pulmonary and systemic vasodilator
-activates beta adrenergic receptors via G protein coupled receptors.
Increases HR and contractility, with decreased SVR (Increased SBP; decreased DBP and MAP)
How is Isoproterenol metabolized and eliminated?
-rapidly metabolized in the liver by COMT (need infusion!)
-40-50% eliminated unchanged in the kidneys
What is the typical dose for Isoproterenol?
1-5mcg/min (infusion 0.5-10mcg/min)
When should you avoid Isoproterenol?
What is the e 1/2 life of Isoproterenol?
What is the onset and DOA of Isoproterenol?
DOA: 5-10 minutes
What are the side effects of Isoproterenol?
-decreased coronary BF 2dary to decreased DBP
-increased oxygen consumption d/t inotrope and chronotrope effects
-peripheral vasodilation and hypotension
What are the contraindications to Isoproterenol?
-Tachycardia caused by Dig toxicity
-CAD and angina