Flashcards in Isoproterenol Deck (12):
What is the trade name of Isoproterenol?
What is the drug classification of Isoproterenol?
Synthetic catecholamine, selective for beta adrenergic receptors
What are the primary uses of Isoproterenol?
-chronotropic agent for heart transplant
-"chemical pacemaker" for heart block and bradydysrhythmias
-mild pulmonary vasodilating effects (reduce PulmVR)
What is the MOA of Isoproterenol?
Provides non-selective beta-adrenergic stimulation of Beta 1 > Beta 2
-also a pulmonary and systemic vasodilator
-activates beta adrenergic receptors via G protein coupled receptors.
Increases HR and contractility, with decreased SVR (Increased SBP; decreased DBP and MAP)
How is Isoproterenol metabolized and eliminated?
-rapidly metabolized in the liver by COMT (need infusion!)
-40-50% eliminated unchanged in the kidneys
What is the typical dose for Isoproterenol?
1-5mcg/min (infusion 0.5-10mcg/min)
When should you avoid Isoproterenol?
What is the e 1/2 life of Isoproterenol?
What is the onset and DOA of Isoproterenol?
DOA: 5-10 minutes
What are the side effects of Isoproterenol?
-decreased coronary BF 2dary to decreased DBP
-increased oxygen consumption d/t inotrope and chronotrope effects
-peripheral vasodilation and hypotension
What are the contraindications to Isoproterenol?
-Tachycardia caused by Dig toxicity
-CAD and angina