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Flashcards in Isoproterenol Deck (12):
1

What is the trade name of Isoproterenol?

Isuprel

2

What is the drug classification of Isoproterenol?

Synthetic catecholamine, selective for beta adrenergic receptors

3

What are the primary uses of Isoproterenol?

-chronotropic agent for heart transplant
-"chemical pacemaker" for heart block and bradydysrhythmias
-mild pulmonary vasodilating effects (reduce PulmVR)

4

What is the MOA of Isoproterenol?

Provides non-selective beta-adrenergic stimulation of Beta 1 > Beta 2
-also a pulmonary and systemic vasodilator
-activates beta adrenergic receptors via G protein coupled receptors.
Increases HR and contractility, with decreased SVR (Increased SBP; decreased DBP and MAP)

5

How is Isoproterenol metabolized and eliminated?

-rapidly metabolized in the liver by COMT (need infusion!)
-40-50% eliminated unchanged in the kidneys

6

What is the typical dose for Isoproterenol?

1-5mcg/min (infusion 0.5-10mcg/min)

7

When should you avoid Isoproterenol?

CAD!

8

What is the e 1/2 life of Isoproterenol?

2.5-5 minutes

9

What is the onset and DOA of Isoproterenol?

Onset: immediate
DOA: 5-10 minutes

10

What are the side effects of Isoproterenol?

-tachycardia
-dysrhythmias
-decreased coronary BF 2dary to decreased DBP
-increased oxygen consumption d/t inotrope and chronotrope effects
-peripheral vasodilation and hypotension

11

What are the contraindications to Isoproterenol?

-Hypersensitivity
-Tachycardia caused by Dig toxicity
-CAD and angina

12

What are the drug interactions with Isoproterenol?

increased potential for arrhythmias with some general anesthetics and co-administration of other sympathomimetics