Isoproterenol Flashcards

1
Q

What is the trade name of Isoproterenol?

A

Isuprel

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2
Q

What is the drug classification of Isoproterenol?

A

Synthetic catecholamine, selective for beta adrenergic receptors

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3
Q

What are the primary uses of Isoproterenol?

A
  • chronotropic agent for heart transplant
  • “chemical pacemaker” for heart block and bradydysrhythmias
  • mild pulmonary vasodilating effects (reduce PulmVR)
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4
Q

What is the MOA of Isoproterenol?

A

Provides non-selective beta-adrenergic stimulation of Beta 1 > Beta 2
-also a pulmonary and systemic vasodilator
-activates beta adrenergic receptors via G protein coupled receptors.
Increases HR and contractility, with decreased SVR (Increased SBP; decreased DBP and MAP)

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5
Q

How is Isoproterenol metabolized and eliminated?

A
  • rapidly metabolized in the liver by COMT (need infusion!)

- 40-50% eliminated unchanged in the kidneys

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6
Q

What is the typical dose for Isoproterenol?

A

1-5mcg/min (infusion 0.5-10mcg/min)

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7
Q

When should you avoid Isoproterenol?

A

CAD!

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8
Q

What is the e 1/2 life of Isoproterenol?

A

2.5-5 minutes

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9
Q

What is the onset and DOA of Isoproterenol?

A

Onset: immediate
DOA: 5-10 minutes

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10
Q

What are the side effects of Isoproterenol?

A
  • tachycardia
  • dysrhythmias
  • decreased coronary BF 2dary to decreased DBP
  • increased oxygen consumption d/t inotrope and chronotrope effects
  • peripheral vasodilation and hypotension
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11
Q

What are the contraindications to Isoproterenol?

A
  • Hypersensitivity
  • Tachycardia caused by Dig toxicity
  • CAD and angina
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12
Q

What are the drug interactions with Isoproterenol?

A

increased potential for arrhythmias with some general anesthetics and co-administration of other sympathomimetics

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