Fospropofol Flashcards Preview

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Flashcards in Fospropofol Deck (9):
1

What are the trade names for Fospropofol?

Aquavan, Lusedra

2

What is Fospropofol approved for?

MAC sedation

3

What is Fospropofol? (ie. how does it work?)

-H2O soluble prodrug of propofol (eliminates the need for lipid formulation- responsible for the risk of pain on injection, infection, hypertriglycerides, PE)

4

How is Fospropofol metabolized?

Hydrolyzed after injection to propofol via endothelial cell alkaline phosphatases

5

What are the advantages of Fospropofol?

-avoiding lipid formulation related complications
-if using low doses less episodes of apnea (slower onset of peak effect)

6

What are the disadvantages to Fospropofol?

-SLOWER peak effect, LONGER duration; may be more difficult to titrate (b/c different metabolism variability)
-Short period of tachycardia
-transient paresthesias and pruritis

7

Why is Fospropofol hard to titrate?

Delayed time to peak effect- increases the difficulty of titrating a drug with a steep response curve and narrow margin of safety

8

What type of metabolism does Fospropofol go through?

Non-linear metabolism to active drug:
-the higher the dose the more hydrolyzed
-the lower the dose the less hydrolyzed (less of the active metabolite propofol released)

9

Compared with propofol, Fospropofol is:

-more potent
-higher Vd (because it is more lipid soluble once in the body)