Flashcards in Alfentanil Deck (29)
What is the trade name of Alfentanil?
What is the formal drug class of Alfentanil?
tetrazole derivative of fentanyl
analgesic and opioid receptor agonist
What are the uses of Alfentanil?
-rapid onset makes it ideal for analgesia when noxious stimulation is acute, but transient, as associated with laryngoscopy, tracheal intubation, and performance of a retrobulbar block
-analgesic adjunct in the maintenance of anesthesia with barbiturates or N2O or as primary anesthetic agent for the unduction of anesthesia
What is the MOA of Alfentanil?
mu-opioid receptor agonist
mu, kappa, delta
-drug binds to stereospecific receptors at many sites within the CNS, increases the pain threshold, alters pain perception and inhibits ascending pain pathways
What is the onset of action of Alfentanil?
RAPID- effect site equilibration time is 1.4 minutes
What is the DOA of Alfentanil?
30 - 60 minutes
How is Alfentanil metabolized?
N-dealkylation and O-demethylation in the liver to form inactive metabolites
What is the major metabolite? is it active?
Noralfentanil, it is NOT active
What is the elimination 1/2 life of Alfentanil?
83 - 97 minutes (1.5 hrs)
What is the Vd of Alfentanil?
4 - 6 times smaller than Fentanyl. This is due to lesser lipid solubility and higher protein binding
Is Alfentanil protein bound?
92% protein bound
What are the CNS effects of Sufentanil?
-muscle rigidity of neck, extremeties, chest wall, abdomen,
What are the Resp side effects of Sufentanil?
What are the CV effects of Sufentanil?
What are theGI side effects of Sufentanil?
increase in biliary tract pressure
What type of drugs may increase levels of sufentanil?
What is the analgesia dose of Alfentanil?
5 - 30 mcg/ kg (followed by infusion of 0.4 - 1.7 mcg/kg/min)
What is the induction dose of Alfentanil?
50 - 200 mcg/kg
What is Alfentanil an analogue of?
____% exists in an unionized state= ?
90%= VERY rapid onset (1.4 min compared to Fentanyl, 6.8 min and sufentanil 6.2 min)
Is alfentanil highly protein bound?
YES, but highly diffusable
Is alfentanil's diffusion fraction higher, lower, or the same as fentanyl? Why is this weird?
HIGHER diffusible fraction than Fentanyl despite more intense protein binding
____ as potent as Fentanyl? _____-___ x more potent than morphine
1/5th; 10 -20
What is the clinical significance of Alfentanil?
-rapid onset is useful for blunting hemodynamic response to noxious stimuli
-rapid effect due to 90% of drug in non-ionized form
-used as infusion for outpatient surgery
What is the dosage of Alfentanil?
10 -20 mcg/kg
What isthe infusion rate of Alfentanil?
0.25 - 0.75 mcg/kg/min
What is the loading dose of Alfentanil?
25 - 100mcg/kg
What is the maintenance infusion rate of Alfentanil?
0.5 - 2 mcg/kg/min