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Flashcards in Sufentanil Deck (37):
1

What is the trade name of Sufentanil?

Sufenta

2

What is the drug class of Sufentanil?

phenylpiperidine opioid agonist

3

What are the uses of Sufentanil?

-analgesic adjunct in maintenance of balanced anesthesia
-can be used as primary anesthetic agent for induction and maintenance
-can be used in management of chronic severe pain with PCP or transdermal patches

4

What is the MOA of sufentanil?

binds to opioid receptors particularly the mu receptors, throughout the central and peripheral nervous sytem
-produces dose related attenuation of catecholamine release, especially NE
-increase of pain threshold, alteration of pain perception, and inhibition of ascending pathways

5

How is Sufentanil metabolized?

Liver and small intestine: major sites of biotransformation

6

What compartment model describes the distribution of Sufentanil?

3 compartment model-- highly lipid soluble

7

What is the potency of Sufentanil as compared to Fentanyl?

5 - 10 times more potent than Fentanyl

8

What is the onset of action of Sufentanil?

1 - 3 minutes

9

What is the elimination 1/2 life of Sufentanil?

164 minutes in adults; approximately 80% of the dose administered is excreted within 24hrs, and 2% eliminated unchanged

10

Is Sufentanil protein bound?

approx 93% protein bound

11

What is the Vd of Sufentanil?

2.86 L/kg

12

What are the CV side effects of Sufentanil?

-Hypotension
-Bradycardia
-Arrhythmia
-Tachycardia
-Cardiac Arrest

13

What is the respiratory effects of Sufentanil?

Respiratory depression
Apnea
Bronchoconspasm

14

What are the Skeletal muscle effects of Sufentanil?

Chest Wall rigidity
Skeletal muscle rigidity of neck and extremeties

15

What are the CNS effects of Sufentanil?

Confusion
Somnolence
Chills

16

What are the Dermatological effects of Sufentanil?

Pruritis
Erythema

17

What are the GI side effects of Sufentanil?

Constipation
N/V
Biliary Spasm

18

What are the GU side effects of Sufentanil?

Urinary Retention

19

What are the contraindications to the use of Sufentanil?

-hypersensitivity
-severe asthma
-paralytic ileus
-use caution in pts with resp disease

20

What drugs increase the levels/effects of sufentanil?

CYP3A4 inhibitors:
-Azole antifungals
-Nefazodone
-Nicardipine
-Propofol
-Protease inhibitors
-Quinidine
-Verapamil

21

What drugs enhance the magnitude and duration of CNS and CV effects when administered with Sufentanil?

-Barbiturates
-Tranquilizers
-Other opioids
-GAs
-CNS depressants

22

How should dosing of Sufentanil be planned?

according to ideal body weight, physical status, underlying pathological conditions, use of other drugs, and type of surgical procedure and anesthesia

23

When should you reduce the dose of Sufentanil?

elderly, debilitated, and neonates

24

What is the analgesia bolus dose of Sufentanil?

0.1 - 1 mcg/kg

25

What is the induction/maintenance dose of Sufentanil for minor procedures?

1 - 2 mcg/kg (balanced technique)

26

What is the Epidural dose of Sufentanil?

10 - 15mcg

27

What is sufentanil an analogue of?

fentanyl

28

_____ x as lipid soluble as Fentanyl

2

29

Only _____% is un-ionized

20%

30

What is Fentanyl's metabolite? is it active?

-desmethylsufentanil
-weakly active

31

_______x more potent than fentanyl

10

32

_______ x more potent than morphine

1,000

33

What is the clinical significance of Sufentanil?

-used as adjunct for surgery and induction
-compared to morphine and fentanyl produces quicker induction earlier emergence and earlier extubation
-used as infusion for outpatient surgery

34

What is the loading dose of Sufentanil?

0.25--2 mcg/kg

35

What is the IV dose of Sufentanil?

0.1 - 0.3 mcg/kg (per dr e)

36

What is the infusion rate of Sufentanil?

0.0015 - 0.01 mcg/kg/min (per Dr. E)

37

What is the maintenance infusion rate of Sufentanil?

0.5 - 1.5 mcg/kg/hr