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Flashcards in Sufentanil Deck (37)
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1
Q

What is the trade name of Sufentanil?

A

Sufenta

2
Q

What is the drug class of Sufentanil?

A

phenylpiperidine opioid agonist

3
Q

What are the uses of Sufentanil?

A
  • analgesic adjunct in maintenance of balanced anesthesia
  • can be used as primary anesthetic agent for induction and maintenance
  • can be used in management of chronic severe pain with PCP or transdermal patches
4
Q

What is the MOA of sufentanil?

A

binds to opioid receptors particularly the mu receptors, throughout the central and peripheral nervous sytem

  • produces dose related attenuation of catecholamine release, especially NE
  • increase of pain threshold, alteration of pain perception, and inhibition of ascending pathways
5
Q

How is Sufentanil metabolized?

A

Liver and small intestine: major sites of biotransformation

6
Q

What compartment model describes the distribution of Sufentanil?

A

3 compartment model– highly lipid soluble

7
Q

What is the potency of Sufentanil as compared to Fentanyl?

A

5 - 10 times more potent than Fentanyl

8
Q

What is the onset of action of Sufentanil?

A

1 - 3 minutes

9
Q

What is the elimination 1/2 life of Sufentanil?

A

164 minutes in adults; approximately 80% of the dose administered is excreted within 24hrs, and 2% eliminated unchanged

10
Q

Is Sufentanil protein bound?

A

approx 93% protein bound

11
Q

What is the Vd of Sufentanil?

A

2.86 L/kg

12
Q

What are the CV side effects of Sufentanil?

A
  • Hypotension
  • Bradycardia
  • Arrhythmia
  • Tachycardia
  • Cardiac Arrest
13
Q

What is the respiratory effects of Sufentanil?

A

Respiratory depression
Apnea
Bronchoconspasm

14
Q

What are the Skeletal muscle effects of Sufentanil?

A

Chest Wall rigidity

Skeletal muscle rigidity of neck and extremeties

15
Q

What are the CNS effects of Sufentanil?

A

Confusion
Somnolence
Chills

16
Q

What are the Dermatological effects of Sufentanil?

A

Pruritis

Erythema

17
Q

What are the GI side effects of Sufentanil?

A

Constipation
N/V
Biliary Spasm

18
Q

What are the GU side effects of Sufentanil?

A

Urinary Retention

19
Q

What are the contraindications to the use of Sufentanil?

A
  • hypersensitivity
  • severe asthma
  • paralytic ileus
  • use caution in pts with resp disease
20
Q

What drugs increase the levels/effects of sufentanil?

A

CYP3A4 inhibitors:

  • Azole antifungals
  • Nefazodone
  • Nicardipine
  • Propofol
  • Protease inhibitors
  • Quinidine
  • Verapamil
21
Q

What drugs enhance the magnitude and duration of CNS and CV effects when administered with Sufentanil?

A
  • Barbiturates
  • Tranquilizers
  • Other opioids
  • GAs
  • CNS depressants
22
Q

How should dosing of Sufentanil be planned?

A

according to ideal body weight, physical status, underlying pathological conditions, use of other drugs, and type of surgical procedure and anesthesia

23
Q

When should you reduce the dose of Sufentanil?

A

elderly, debilitated, and neonates

24
Q

What is the analgesia bolus dose of Sufentanil?

A

0.1 - 1 mcg/kg

25
Q

What is the induction/maintenance dose of Sufentanil for minor procedures?

A

1 - 2 mcg/kg (balanced technique)

26
Q

What is the Epidural dose of Sufentanil?

A

10 - 15mcg

27
Q

What is sufentanil an analogue of?

A

fentanyl

28
Q

_____ x as lipid soluble as Fentanyl

A

2

29
Q

Only _____% is un-ionized

A

20%

30
Q

What is Fentanyl’s metabolite? is it active?

A
  • desmethylsufentanil

- weakly active

31
Q

_______x more potent than fentanyl

A

10

32
Q

_______ x more potent than morphine

A

1,000

33
Q

What is the clinical significance of Sufentanil?

A
  • used as adjunct for surgery and induction
  • compared to morphine and fentanyl produces quicker induction earlier emergence and earlier extubation
  • used as infusion for outpatient surgery
34
Q

What is the loading dose of Sufentanil?

A

0.25–2 mcg/kg

35
Q

What is the IV dose of Sufentanil?

A

0.1 - 0.3 mcg/kg (per dr e)

36
Q

What is the infusion rate of Sufentanil?

A

0.0015 - 0.01 mcg/kg/min (per Dr. E)

37
Q

What is the maintenance infusion rate of Sufentanil?

A

0.5 - 1.5 mcg/kg/hr