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Flashcards in Ketamine Deck (41)
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What are the trade names for Ketamine?

Ketalar or Ketaject


What is the formal drug class of Ketamine?

-General anesthesia induction agent; phencyclidine derivative
-N-methyl-D-aspartate (NMDA) receptor antagonist


What are the uses of Ketamine?

Causes intense analgesia at subanesthetic doses and produces prompt induction of anesthesia when administered IV at higher doses


What is the MOA of Ketamine?

-Ketamine's CNS effects are dose dependent and are related to its antagonistic activity at the NMDA receptor
-Glutamate and NMDA are excitatory amino acids. When glutamate binds to the NMDA subtype of the glutamate receptor, the channel opens and allows Na, K, Ca to either enter or leave the cell. Flux of these ions depolarize the POSTsynaptic neuron and initiate an action potential. ***Ketamine blocks this open channel and prevents further ion influx, thus inhibiting the excitatory response to glutamate
-dissociative anesthesia
-evidence that Ketamine depresses transmission of impulses in the medial medullary reticular formation, which is important for transmission of the affective-emotional components of nocioception from the spinal cord to higher brain centers
-it also binds with opioid, cholinergic, and monoaminergic(involves descending inhibitory pathways for antinocioception) receptors
-Ketamine inhibits neuronal sodium channels (producing a modest local anesthetic action) and calcium channels (causing cerebral vasodilation)


How does Ketamine produce "dissociative anesthesia"?

there is depression of neuronal function in association areas of the cerebral cortex and thalamus while stimulation of the hippocampus (limbic systems) producing a marked sensory loss and analgesia, as well as amnesia; basically you are getting the information to the thalamus, but you are not integrating the info appropriately! ie pt sees the light in the OR as falling bricks....


How is Ketamine metabolized?

Hepatic microsomal enzymes
-an important pathway in metabolism is demethylation of Ketamine by CYP450 enzymes to form NORKETAMINE. Norketamine is eventually hydroxylatedand then conjugated to form more water-soluble and inactive glucuronide metabolites that are excreted by the kidneys
-1st pass effect!!


After IV administration of Ketamine, where do you see Ketamine being eliminated?

< 4% of a dose can be recovered from the urine unchanged
Fecal excretion accounts for < 5% of an injected dose


Why does Ketamine cross the BBB so rapidly (3)?

-has low-molecular weight
-a pKa near the physiologic pH, and
-relatively high lipid solubility


What is the onset of action of Ketamine?

30-60 seconds


When does the maximal effect of Ketamine occur?

within 1 minute of IV administration


What is the volume of distribution of Ketamine?

large distribution volume (3 L/kg) ; 2 compartment model-> high lipid solubility-> large Vd!
redistribution is a factor!!


What is the E 1/2 life of Ketamine?

2 - 3 hours


Is Ketamine protein bound?

approximately 12% protein bound


What is the major drawback to Ketamine administration?

Hallucination and
Emergence Delirium


What are the CNS side effects of Ketamine?

-Increased ICP and IOP
-increases CBF, CMRO2
-dose related depression of LOC
-Seizure like activity
-Nystagmus, pupil dilation
-SALIVATION, lacrimation
-Myoclonic activity
-SNS stimulation
-Emergence delirium
-Vivid dreaming
-Extracorporeal experiences


What are the CV side effects of Ketamine?

-Direct Myocardial depressant but does cause intense SNS stimulation resulting in Tachycardia, HTN, Increased CO in those with normal catecholamine stores
-increases BP, HR, CO
-Inhibits reuptake of NE
-increases myocardial work and O2 consumption


What are the Respiratory side effects of Ketamine?

-Increased PulmVR
-Bronchodilation (SNS Stimulation)
-Respiratory depression especially in children when given as a bolus
-Causes increased salivation which has cause upper respiratory obstruction and can promote laryngospasm
-NO alteration in CO2 response


What are the contraindication for use of Ketamine? (6)

-Patients with increased ICP or reduced cerebral compliance
-Ketamines preservative, chlorobutanol, is neurotoxic; this formation of Ketamine for subarachnoid or epidural administration is CONRAINDICATED
-patients with open eye surgery or other ophthalmic disorders
-in patients with significant CAD, pulmonary HTN, or elevation of BP and in those who have shown hypersensitivity to the drug
-as sole anesthetic in ischemic heart disease/CAD
-patients with severe psychiatric disorders such as schizophrenia
-avoid in DTs b/c of emergence delirium


What drug should you consider giving with Ketamine? Why?

Benzodiazepine to reduce the incidence of hallucinations and emergence reactions


What can happen if Ketamine is administered in the presence of volatile anesthetics?

may result in hypotension


Name the drugs that cause an interaction with Ketamine....we will go in to detail lataaa

Volatile Anesthetics


What drug interaction occurs between Ketamine and Verapamil?

the blood pressure-elevating effects of Ketamine may be attenuated, whereas drug induced increases in HR are enhanced


What drug interaction occurs between Ketamine and NDMRs?

Ketamine-induced enhancement of non-depolarizing neuromuscular-blocking agents may reflect interference by Ketamine with Calcium ion binding


What drug interaction occurs between Ketamine and Succinylcholine?

The duration of apnea after administration of succ is prolonged


What drug interaction has been reported with Ketamine and Aminophylline?

Seizures have been described in asthmatic patients receiving aminophylline followed by administration of ketamine


What routes can Ketamine be administered?

IV, IM, transcutaneously, PO, nasally, PR, and as a preservative-free solution epidurally or intrathecally (most clinical use is by IV or IM)


What is the premedicant dose of Ketamine?

Preventative analgesia: 0.15 - 0.25 mg/kg


What is the sedative dosage of Ketamine?

0.2 - 0.5 mg/kg


What is the IV and IM induction of GA dosage of Ketamine?

0.5 - 2 mg/kg IV; 4 -6 mg/kg IM


What is the maintenance dose of Ketamine?

1-2 mg/kg/hr