Flashcards in Naloxone Deck (17)
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1
What is the trade name of Naloxone?
Narcan
2
What is Naloxone? (chemically speaking)
N-allylnoroxymorphine hydrochloride
3
What is the formal drug classification of Naloxone?
nonselective opioid receptor antagonist- COMPETITIVE
4
What is Naloxone used for?
to reverse life threatening SE of opioid administration, specifically respiratory depression
5
What is the MOA of Naloxone?
N-alkyl derivative of oxymorphone
Pure opioid antagonist
Blocks all 3 opioid receptor types and displaces opioids from its receptor sites, which reverses respiratory depression and opioid analgesia
-it is selective for mu receptors when used to treat opioids-induced respiratory depression
-blocks the effects of endogenous and exogenous opioids
6
How is Naloxone metabolized?
primarily metabolized by hepatic conjugation with glucuronic acid to form naloxone-3-glucuronide
7
What is the onset of action for Naloxone?
Rapid IV 1-2min
8
What is the DOA of Naloxone?
short 30 - 60 minutes
-this makes supplemental doses of Naloxone necessary for sustained opioid antagonim
9
How is Naloxone eliminated?
kidneys as metabolites
10
What is the elimination 1/2 time of Naloxone?
1 - 1.5 hours
11
What is the dose of Naloxone?
0.1 - 2 mg IV/IM/SC repeat in 2 -3 minutes as needed
12
What are the CNS effects of Naloxone?
Rapid awakening
Pain
Irritability
Anxiety
Restlessness
Seizures
Tremulousness
--due to opioid withdrawal...
13
What are the resp. effects of Naloxone?
pulmonary edema (esp. in CV disease!)
14
What are the CV effects of Naloxone?
HTN
Tachycardia
Ventricular arrhythmias
Cardiac Arrest
Increased SNS activity!
15
What are the GI effects of Naloxone?
N/V/D
16
Reversal is ________ __________
dose dependent
17
