Naloxone Flashcards
Please note that the drug card information is for Educational Use ONLY, and the source is from Carrie Bowman's glossary of drug cards permitted by use of Georgetown NAP students. No permission is given to use these cards for anything other than as a study resource for our program. (17 cards)
What is the trade name of Naloxone?
Narcan
What is Naloxone? (chemically speaking)
N-allylnoroxymorphine hydrochloride
What is the formal drug classification of Naloxone?
nonselective opioid receptor antagonist- COMPETITIVE
What is Naloxone used for?
to reverse life threatening SE of opioid administration, specifically respiratory depression
What is the MOA of Naloxone?
N-alkyl derivative of oxymorphone
Pure opioid antagonist
Blocks all 3 opioid receptor types and displaces opioids from its receptor sites, which reverses respiratory depression and opioid analgesia
-it is selective for mu receptors when used to treat opioids-induced respiratory depression
-blocks the effects of endogenous and exogenous opioids
How is Naloxone metabolized?
primarily metabolized by hepatic conjugation with glucuronic acid to form naloxone-3-glucuronide
What is the onset of action for Naloxone?
Rapid IV 1-2min
What is the DOA of Naloxone?
short 30 - 60 minutes
-this makes supplemental doses of Naloxone necessary for sustained opioid antagonim
How is Naloxone eliminated?
kidneys as metabolites
What is the elimination 1/2 time of Naloxone?
1 - 1.5 hours
What is the dose of Naloxone?
0.1 - 2 mg IV/IM/SC repeat in 2 -3 minutes as needed
What are the CNS effects of Naloxone?
Rapid awakening Pain Irritability Anxiety Restlessness Seizures Tremulousness --due to opioid withdrawal...
What are the resp. effects of Naloxone?
pulmonary edema (esp. in CV disease!)
What are the CV effects of Naloxone?
HTN Tachycardia Ventricular arrhythmias Cardiac Arrest Increased SNS activity!
What are the GI effects of Naloxone?
N/V/D
Reversal is ________ __________
dose dependent
Why is naloxone not benign?
reversal of opioid effect you get tachy, htn, ventricular dysrhythmias, sever pain also pulm edema
- pulm edema in pts with CV disease
- can induce pulm edema in healthy patients due to catecholamine release
