Flashcards in Naloxone Deck (17)
What is the trade name of Naloxone?
What is Naloxone? (chemically speaking)
What is the formal drug classification of Naloxone?
nonselective opioid receptor antagonist- COMPETITIVE
What is Naloxone used for?
to reverse life threatening SE of opioid administration, specifically respiratory depression
What is the MOA of Naloxone?
N-alkyl derivative of oxymorphone
Pure opioid antagonist
Blocks all 3 opioid receptor types and displaces opioids from its receptor sites, which reverses respiratory depression and opioid analgesia
-it is selective for mu receptors when used to treat opioids-induced respiratory depression
-blocks the effects of endogenous and exogenous opioids
How is Naloxone metabolized?
primarily metabolized by hepatic conjugation with glucuronic acid to form naloxone-3-glucuronide
What is the onset of action for Naloxone?
Rapid IV 1-2min
What is the DOA of Naloxone?
short 30 - 60 minutes
-this makes supplemental doses of Naloxone necessary for sustained opioid antagonim
How is Naloxone eliminated?
kidneys as metabolites
What is the elimination 1/2 time of Naloxone?
1 - 1.5 hours
What is the dose of Naloxone?
0.1 - 2 mg IV/IM/SC repeat in 2 -3 minutes as needed
What are the CNS effects of Naloxone?
--due to opioid withdrawal...
What are the resp. effects of Naloxone?
pulmonary edema (esp. in CV disease!)
What are the CV effects of Naloxone?
Increased SNS activity!
What are the GI effects of Naloxone?
Reversal is ________ __________