Acid-Base Homeostasis Flashcards Preview

EMS - Mechanisms Of Disease > Acid-Base Homeostasis > Flashcards

Flashcards in Acid-Base Homeostasis Deck (17):
1

What contributes to acid production in the body?

CO2,
unmetabolised acids
plasma [H+]

2

What are the sites of Acid-base metabolism?

-lungs
-kidney
-GI tract
-Liver

3

In the Oxygen-Haemoglobin dissociation curve what does a right shift indicate/

Right shift with
Increased
2,3 diPG
Acidosis H+
Temperature

*oxygen dissociates more easily here

4

Where in the kidneys is bicarbonate reclaimed?

convuluted tubules

5

How is acid-base homeostasis maintained in the GI tract?

Stomach produces H+.
Pancreas produced HCO3-

6

What is the Liver's role in acid-base homeostasis?

-Lactate is metabolised in the liver.
-Urea is synthesised in the liver
-proteins and amino acids are processed here (release of NH4+)

7

What occurs in severe liver failure?

Metabolic alkalosis
NH4+ toxicity

8

How do we compensate for acidosis?

1) Renal bicarbonate regeneration.
2) Hepatic shift between urea synthesis (inhibited by acidosis) and ammonia excretion (stimulated by alkalosis)

9

What causes metabolic Acidosis?

1) increased H+ formation
2) Acid ingestion
3) reduced renal H+ excretion
4) loss of bicarbonate

10

What causes metabolic alkalosis?

1) generation of bicarbonate by gastric mucosa
2) Renal generation of bicarbonate
3) administration of bicarbonate

11

What is decreased H+, increased pCO2, decreased pCO2?

Metabolic alkalosis

12

What is increased H+, decreased pCO2, increased pO2?

Metabolic Acidosis

13

What is increased H+, increased pCO2 and decreased pO2 a sign of?

Respiratory acidosis

14

What is decreased H+, Decreased pCO2 and increased pO2 a sign of?

Respiratory Alkalosis

15

What are the causes of increased H+ formation?

1) alcoholic / diabetic ketoacidosis (breakdown of fats and amino acid for energy)
2) lactic acidosis
3)poisoning

16

What can result from asthma?

Acidosis

17

What can occur in renal failure?

Reduced nephrons leads to:
-increased bicarb loss
-reduced NH4+ excretion

ACIDOSIS