Micro-organisms in Disease : Infection Flashcards Preview

EMS - Mechanisms Of Disease > Micro-organisms in Disease : Infection > Flashcards

Flashcards in Micro-organisms in Disease : Infection Deck (22):
1

What is the chain of infection

1) Pathogenic organism
2) Reservoir
3) Exit
4) Transmission
5) Entry
6) Susceptible host

2

What is the name given to describe the degree to which a micro-organism is able to cause disease.

Virulence

3

What is the name given to describe the ability of a micro-organism to become established on or in a host

Infectivity

4

What are components of micro-organisms that result in harmful effects called?

Virulence factors

5

What virulence factor is a component of Gram negative bacterial cell walls, released from damaged/ dead cells and binds to a number of host cell receptors to induce a range of uncontrolled host cell responses?

Endotoxin

6

What is the host response to endotoxin?

Systemic Inflammatory response syndrome (SIRS)
-uncontrolled T cell response
-uncontrolled activation of the clotting cascade
-uncontrolled activation of complement

7

What is botulism?

Clostridium botulinim
releases toxins. can gain entry via contaminated food, infection of dirty wounds. The toxin attacks the nervous system causing muscle weakness and paralysis.

8

Diplopia
Dysphagia
Dysarthria
Dry mouth
death (due to respiratory failure)
are all clinical features of...

Botulism

9

Tetanus

Toxin produced by Clostridium Tetani causes Jaw spasms, whole body siezures.
Death by respiratory paralysis

10

Bordetella pertussis causes

Whooping Cough

11

Vibrio Cholerae causes

Cholera

12

Corynebacterium diptheriae causes

Diphtheria

13

Clostridium Difficile

Diarrhoea / pseudomembranous colitis

14

Scarlet fever is caused by

Streptococcus pyogenes

15

What bacteria has virulence factors which promote connective tissue breakdown and invasion?

Streptococcus pyogenes

16

What bacteria causes:
Streptococcal sore throat
Erysipelas (red pathy skin)
Necrotizing fasciitis
Scarlet fever

Streptococcus Pyogenes

17

Strep Pyogenes, Virulence factors:
Hyaluronidase / streptokinase

Break down connective tissue compenents and fascilitate tissue invasion

18

Strep Pyogenes Virulence factors
C5a peptidase

Inactivated complement C5a

19

Strep Pyogenes, Virulence factors:
Streptolysins -O and -H

Lyse red and white blood cells and platelets

20

Strep Pyogenes, Virulence factors:
Erythrogenic tosin

causes the rash of scarlet fever

21

What are the 3 components which make up viruses?

1) DNA / RNA
2) Capsid Protein
3) Envelope

22

What is the virus life cycle?

1) Adsorption
2) Penetration
3) Uncoating
4) Synthesis
5) Assembly
6) Release