Repair and Regeneration Flashcards Preview

EMS - Mechanisms Of Disease > Repair and Regeneration > Flashcards

Flashcards in Repair and Regeneration Deck (13):
1

What is regeneration?

-Damaged tissue returns to normal.
-Regains specialised function

2

What is repair?

-The damaged cells cannot be replaced, leads to fibrosis and scarring.
-Loss of specialised function.

3

What are liable cell populations?

Liable cell populations have:
1) high normal turnover
2)Active stem cell population
3)Excellent regenerative capacity

e.g. Epithelia

4

What are stable (quiescent cell populations)?

Stable (quiescent) cell populations have:
1) low turnover
2)Turnover can increase if needed
3) good regenerative capacity

e.g. Liver, renal tubules

5

What are permanent cell populations?

Permanent cell populations :
1) no turnover
2) minimal / no regenerative capacity

e.g. neurons, muscle cells (however research is being conducted in this area)

6

How is regeneration controlled?

-PROLIFERATION of stem cells covering of defect (cells at edges of defect can proliferate to COVER the injury)

-Contact INHIBITION (once a layer has formed, proliferation is switched off)

-Controlled by growth factors, cell-cell and cell-matrix interactions.

7

What does regeneration depend on?

-tissue cell kinetics and architecture
-stem cell survival

8

What is the role of myofibroblasts in granulation tissue formation?

-Myofibroblasts synthesis collagen and extracellular matrix.
-granulation tissue gains myofibrils
-has contractile ability

WOUND CONTRACTION

9

What are the possible effects of wound contraction - give examples?

1) Oesophageal peptic strictures - scar tissue contracts to form a narrowing of the oesophagus >>>>swallowing problems

10

What local factors inhibit healing?

1) infection
2)Haematoma
3)Blood supply
4) foreign bodies

11

What systemic factors inhibit healing?

1) age
2) drugs
3) anaemia
4) diabetes
5) malnutrition
6) Vit C deficiency

12

What type of bone heals fractures

Lamellar bone

13

How does healing occur in the brain?

The supporting tissue in the brain is made of glial cells (not collagen + fibroblasts)

-cyst formation

-Gliosis rather than scarring