Flashcards in Chronic Inflammation Deck (14):
What is the purpose of inflammation?
1) remove cause of injury
2) Remove necrosis
3) Initiate repair
What immune cells cause chronic and acute inflammation?
Acute = neutrophils
Chronic = Machrophages, Lymphocytes, fibroblasts.
Chronic inflammation can be primary or develop from acute. In what ways can this happen?
Progression from acute to chronic inflammation is most common is supporative (pus forming) inflammation.
Pus can form an abscess.
Granulation and fibrous tissue forms.
Recurrent acute inflammation can lead to chronic
What are the features of chronic inflammation?
1) Infiltration with mononuclear cells
2) Tissue destruction
3) Healing by fibrosis (new fibrous scar tissue from granulation tissue)
4) (exudation fluid NOT prominent)
What is the role of macrophages in chronic inflammation?
1) macrophages are V. importnant in Chronic Inflammation
2) they secrete cytokines at sight of damage which recruit monocytes
3)Macrophages proliferate in the damaged tissue and get immobilised.
What are monocytes?
Monocytes are in the blood stream and differentiate into macrophages or dendritic cells once in tissue
What is the persistent accumulation of macrophages in chronic inflammatory tissue due to?
1) continued recruitment of monocytes (due to secretion of cytokines)
2) local proliferation of macrophages
3) immobilisation in macrophages
What happens during wound healing ?
1) Granulation tissue froms by :
2) Angiogenesis (development of new blood vessels)
3) Fibroblasts deposit collagen
4) Inflammatory cells
What is fibrosis?
thickening or scarring of connective tissue during repair of damaged tissue
Give examples of granulomatous diseases?
What is a granuloma?
Granuloma = nodule of activated macrophages (epithelioid histiocytes), lymphocytes and histiocytic giant cells (ie. giant macrophages)
What are histiocytic giant cells and how to the develop?
- when material is indigestible to macrophages Histiocytic giant cells can form.
-When 2 or more macrophages try to engulf the same particle a giant cell can form
-they are not phagocytic
How is inflammation associated with cardiovascular diseases ?
- Chronic inflammation in response to MI
-Macrophages process lipids in plaque and become foam cells.