Chronic Inflammation Flashcards Preview

EMS - Mechanisms Of Disease > Chronic Inflammation > Flashcards

Flashcards in Chronic Inflammation Deck (14):
1

What is the purpose of inflammation?

1) remove cause of injury
2) Remove necrosis
3) Initiate repair

2

What immune cells cause chronic and acute inflammation?

Acute = neutrophils
Chronic = Machrophages, Lymphocytes, fibroblasts.

3

Chronic inflammation can be primary or develop from acute. In what ways can this happen?

Progression from acute to chronic inflammation is most common is supporative (pus forming) inflammation.

Pus can form an abscess.

Granulation and fibrous tissue forms.

Recurrent acute inflammation can lead to chronic

4

What are the features of chronic inflammation?

1) Infiltration with mononuclear cells

2) Tissue destruction

3) Healing by fibrosis (new fibrous scar tissue from granulation tissue)

4) (exudation fluid NOT prominent)

5

What is the role of macrophages in chronic inflammation?

1) macrophages are V. importnant in Chronic Inflammation

2) they secrete cytokines at sight of damage which recruit monocytes

3)Macrophages proliferate in the damaged tissue and get immobilised.

6

What are monocytes?

Monocytes are in the blood stream and differentiate into macrophages or dendritic cells once in tissue

7

What is the persistent accumulation of macrophages in chronic inflammatory tissue due to?

1) continued recruitment of monocytes (due to secretion of cytokines)

2) local proliferation of macrophages

3) immobilisation in macrophages

8

What happens during wound healing ?

1) Granulation tissue froms by :

2) Angiogenesis (development of new blood vessels)

3) Fibroblasts deposit collagen

4) Inflammatory cells

9

What is fibrosis?

thickening or scarring of connective tissue during repair of damaged tissue

10

Give examples of granulomatous diseases?

Bacterial:
TB
Leprosy

Parasitic:
Schistosomiasis

Fungal:
Cryptococcus

Unknown:
Sarcoidosis
Crohn's

11

What is a granuloma?

Granuloma = nodule of activated macrophages (epithelioid histiocytes), lymphocytes and histiocytic giant cells (ie. giant macrophages)

12

What are histiocytic giant cells and how to the develop?

- when material is indigestible to macrophages Histiocytic giant cells can form.

-When 2 or more macrophages try to engulf the same particle a giant cell can form

-they are not phagocytic

13

How is inflammation associated with cardiovascular diseases ?

- Chronic inflammation in response to MI

-Atheroma formation:
-Macrophages process lipids in plaque and become foam cells.

14

What are the causes of chronic inflammation?

-acute Infl
-persistent infection
-autoimmunity
-prolonged exposure to toxins