Acute Inflammation Flashcards Preview

EMS - Mechanisms Of Disease > Acute Inflammation > Flashcards

Flashcards in Acute Inflammation Deck (13):
1

What are the causes of Acute Inflammation?

1) Tissue death by:
-Ischaemia
-Trauma
-Toxins
-Thermal injury
-Radiation

2) Infection
-esp bacterial

2

What is the purpose of acute inflammation?

1) Clear away dead tissues
2) locally protect from infection
3) allow access of immune system components

3

What are the 4 cardinal signs of inflammation?

1) HEAT
2) PAIN
3) REDNESS
4) SWELLING

4

What are the components of the acute Inflammatory response?

1) Vascular reaction (dilation increases blood flow)

2) Exudative reaction (causes swelling)

3) Cellular reaction - migration of inflammatory cells out of vessels

5

what is pyrexia?

raised body temp / fever

6

what is permeability of blood vessels controlled by?

-Histamine
-Bradykinin
-NO
-Leukotriene B4
-Complement compounds

7

What is the cellular reaction in acute inflammation?

-neutrophils accumulate in the extracellular space
-neutrophils + cell debris + bacteria = pus

8

what is they lifespan of neutrophils?

a few hours

9

what are the cell derived mediators of acute inflammation?

stored:
-histamine

synthesised:
-Prostaglandins
-leukotrienes
-cytokines
-NO
-Chemokines

10

what are the plasma derived mediators of acute inflammation?

-kinin system
-clotting pathway
-thrombolytic pathway
-complement pathway

11

what is the role of histamine in acute inflammation?

-vascular dilatation leads to increased permeability

12

In what diseases does the inflammatory pathway to go wrong?

1) Systemic inflammatory response syndrome
2) Acute respiratory distress syndrome
3) chronic granulomatous disease of childhood
4) Hereditary angio-oedema
5) Amyloidosis

13

What are the effects of acute inflammation damage on tissue?

1) Minimal tissue damage can be resolved
2) Some tissue damage can lead to fibrosis
3) Tissue damage with a neutrophilic reaction can cause suppuration (abscess)
4) If damaging agent persists then chronic inflammation can occur