Acute-phase reactants Flashcards
Cytokine that induces acute phase reactants
IL-6
Factors produced by liver in both acute and chronic inflammatory states
Acute phase reactants
Opsonin that fixes complement and facilitates phagocytosis
C-reactive protein (CRP)
Acute phase reactant that is measured clinically as a non-specific sign of ongoing inflammation
CRP
Binds and sequesters iron to inhibit microbial iron scavenging
Ferritin
Coagulation factor that promotes endothelial repair and correlates with ESR
Fibrinogen
Acute phase reactant that inhibits iron absorption by degrading ferroportin and inhibits iron release by macrophages causing anemia of chronic disease
Hepcidin
Prolonged elevation of this acute phase reactant can lead to amyloidosis
Serum amyloid A
Reduction of this protein conserves amino acids for positive acute phase reactants
Albumin
This protein is internalized by macrophages to sequester iron
Transferrin