Antibody structure and function

Question 1

Section of antibody that contains variable/hypervariable regions

Answer 1

Fab region

Question 2

Section of antibody that consists of Light & Heavy chains

Answer 2

Fab region

Question 3

Section of antibody that determines idiotype

Answer 3

Fab region has unique antigen-binding pocket

Question 4

B-cell expresses how many types of antigenic specificity

Answer 4

Only 1

Question 5

Heavy chain contributes to which antibody chain?

Answer 5

Fc and Fab regions

Question 6

Light chain contributes to which antibody chain?

Answer 6

Fab region only

Question 7

Which antibody region determines isotype?

Answer 7

Fc region

Question 8

Antibody region that contains carboxy terminal

Answer 8

Fc region

Question 9

Antibody region that binds complement

Answer 9

Fc region

Question 10

Antibody region that contains carbohydrate side chains

Answer 10

Fc region

Question 11

Generation of antibody diversity is antigen dependent or independent?

Answer 11

Antigen independent

Question 12

Mechanism of antibody diversity

Answer 12

1. Random combination of VJ (light) or V(D)J (heavy) genes
2. Random addition of nucleotides to DNA during recombination by TdT
3. Random combination of heavy-chains with light-chains

Question 13

Generation of antibody specificity is antigen dependent or independent?

Answer 13

Antigen dependent

Question 14

Mechanism of antibody specificity

Answer 14

1. Somatic hypermutation and affinity maturation in variable region
2. Isotype switching in constant region