Innate vs Adaptive Immunity

Question 1

Components of Innate immunity

Answer 1

Neutrophils, macrophages, monocytes, dendritic cells, NK cells (lymphoid origin), complement

Question 2

Duration of innate immunity resistance

Answer 2

Lifelong and does not change within lifetime

Question 3

Innate immunity response to pathogens

Answer 3

Rapid and non-specific; no memory response

Question 4

Physical barriers to innate immunity

Answer 4

Epithelial tight junctions and mucus

Question 5

Proteins secreted by innate immunity

Answer 5

Lysozyme, complement, C-reactive protein, defensins

Question 6

Key features of pathogen recognition in innate immunity

Answer 6

TLRs that recognize bacterial PAMPs like LPS (gram-negative bacteria), flagellin (bacteria), nucleic acids (viruses)

Question 7

Components of adaptive immunity

Answer 7

T-cells, B-cells, circulating antibodies

Question 8

Mechanism of adaptive immunity

Answer 8

Variation through V(D)J recombination during lymphocyte development

Question 9

Duration of resistance in adaptive immunity

Answer 9

Microbial resistance is not heritable

Question 10

Adaptive immunity response to pathogens

Answer 10

Highly specific, refined over time; develops over long periods; memory response is faster and more robust

Question 11

Physical barriers to adaptive immunity

Answer 11

None

Question 12

Proteins secreted by adaptive immunity

Answer 12

Immunoglobulins (IgA, IgG, IgM, IgE)

Question 13

Key features of pathogen recognition in adaptive immunity

Answer 13

Memory cells: activated B and T cells; subsequent exposure to previously encountered antigen leads to a stronger, quicker immune response