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Step 1 Immunology-First Aid 2017 > Helper T cells, Cytotoxic T cells, Regulatory T cells > Flashcards

Helper T cells, Cytotoxic T cells, Regulatory T cells Flashcards

1
Q

Differentiated Helper T-cell

A

Th1, Th2, Th17, T-reg

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2
Q

Cytokine that causes T-cell to change to T-reg

A

TGF-beta

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3
Q

Cytokine that causes T-cell to change to Th17 cell

A

TGF-beta and IL-6

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4
Q

Cytokine that causes T-cell to change to Th2 cell

A

IL-2, IL-4

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5
Q

Cytokine that causes T-cell to change to Th1 cell

A

IL-12, IFN-gamma

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6
Q

Cytokine that inhibits Th1 cell

A

IL-4, IL-10 from Th2 cell

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7
Q

Cytokine that inhibits Th2 cell

A

IFN-gamma from Th1 cell

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8
Q

Th1 cell activates what cell types

A

Macrophages and cytotoxic T-cells

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9
Q

Cytokines secreted by Th1 cell

A

IFN-gamma and IL-2

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10
Q

Cytokines secreted by Th2 cell

A

IL-4, IL-5, IL-6, IL-10, IL-13

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11
Q

Th2 cell induces B cells to secrete…

A

IgE

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12
Q

Th2 cell recruits what immune cell?

A

Eosinophils for parasitic defense

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13
Q

Th1 cells release what to stimulate macrophages?

A

IFN-gamma

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14
Q

T cell differentiation to Th1 is cause by what cells?

A

Release of IL-12 by dendritic cells, macrophages and other APCs

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15
Q

Function of Cytotoxic T cells

A

Kill virus infected, neoplastic or donor graft cells by inducing apoptosis

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16
Q

Mechanism how Cytotoxic T cells induce apoptosis

A

Release cytotoxic granules containing preformed proteins (perforin, granzyme B)

17
Q

Function of Regulatory T Cells (T-regs)

A

Maintain specific immune tolerance by suppressing CD4 and CD8 T-cell effector functions

18
Q

Surface proteins expressed by T-regs

A

CD3, CD4, CD25, FOXP3

19
Q

Anti-inflammatory cytokines produced by activated T-regs

A

IL-10, TGF-beta

20
Q

Genetic deficiency of FOXP3 leading to autoimmunity

A

IPEX (Immune dysregulation, Polyendocrinopathy, Enteropathy, X-linked) syndrome

21
Q

IPEX is associated with what group of individuals

A

Diabetes in male infants

22
Q

IPEX is characterized by…

A

Enteropathy, endocrinopathy, nail dystrophy, dermatitis, and/or other autoimmune dermatologic conditions

Step 1 Immunology-First Aid 2017 (30 decks)

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