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Step 1 Immunology-First Aid 2017 > Therapeutic antibodies > Flashcards

Therapeutic antibodies Flashcards

1
Q

Alemtuzumab target

A

CD52

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2
Q

Alemtuzumab clincal uses

A

CLL, MS

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3
Q

Bevacizumab target

A

VEGF

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4
Q

Bevacizumab clinical uses

A

Colorectal cancer, renal cell carcinoma, non-small cell lung cancer

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5
Q

Cetuximab target

A

EGFR

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6
Q

Cetuximab clincal uses

A

Stage IV colorectal cancer, head and neck cancer

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7
Q

Rituximab target

A

CD20

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8
Q

Rituximab clinical indications

A

B-cell non-Hodgkin lymphoma, CLL, rheumatoid arthritis, Idiopathic thrombocytopenic purpura (ITP)

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9
Q

Trastuzumab target

A

HER2/neu

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10
Q

Trastuzumab clinical uses

A

Breast cancer, gastric cancer

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11
Q

Soluble TNF-alpha drugs

A

Adalimumab, certolizumab, golimumab, infliximab

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12
Q

Adalimumab, certolizumab, golimumab, infliximab target

A

Soluble TNF-alpha

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13
Q

Adalimumab, certolizumab, golimumab, infliximab clinical uses

A

IBD, Rheumatoid arthritis, Ankylosing spondylitis, Psoriasis

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14
Q

TNF-alpha decoy that is not a monoclonal antibody

A

Etanercept

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15
Q

Daclizumab target

A

CD25 (part of IL-2 receptor)

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16
Q

Daclizumab clinical use

A

Relapsing multiple sclerosis

17
Q

Eculizumab target

A

C5 complement protein

18
Q

Eculizumab clinical uses

A

Paroxysmal nocturnal hemoglobinuria

19
Q

Natalizumab target

A

Alpha-4 integrin

20
Q

Natalizumab clinical uses

A

Multiple sclerosis, Crohn disease

21
Q

Risk with natalizumab

A

WBC adhesion, risk of PML in patient with JC virus

22
Q

Ustekinumab target

A

IL-12/IL-23

23
Q

Ustekinumab clincal uses

A

Psoriasis, psoriatic arthritis

24
Q

Abciximab target

A

Platelet glycoproteins IIb/IIIa

25
Q

Abciximab clinical uses

A

Antiplatelet agent prevents ischemia in patients undergoing percutaneous coronary intervention

26
Q

Denosumab target

A

RANKL

27
Q

Denosumab indication

A

Osteoporosis; inhibits osteoclasts maturation

28
Q

Denosumab mimics what

A

Osteoprotegerin

29
Q

Digoxin immune Fab target

A

Digoxin - antidote for digoxin toxicity

30
Q

Omalizumab target

A

IgE - prevents IgE binding to FceRI

31
Q

Omalizumab clinical use

A

Refractory allergic asthma

32
Q

Palivizumab target

A

RSV F protein

33
Q

Palivizumab clinical use

A

RSV prophylaxis for high-risk infants

34
Q

Ranibizumab, bevacizumab target

A

VEGF

35
Q

Ranibizumab, bevacizumab clincal uses

A

Neovascular age-related macular degeneration, proliferative diabetic retinopathy and macular edema

Step 1 Immunology-First Aid 2017 (30 decks)

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