Grafts and Transplant rejection

Question 1

Autograft donor

Answer 1

Self

Question 2

Syngeneic draft donor

Answer 2

Identical twin or clone

Question 3

Allograft donor

Answer 3

Nonidentical individual of same species

Question 4

Xenograft donor

Answer 4

Different species

Question 5

Hyperacute rejection onset

Answer 5

Within minutes

Question 6

Treatment for hyperacute rejection

Answer 6

Remove graft

Question 7

Pre-existing recipient antibodies react to donor antigen and activate complement is seen in what type of transplant rejection

Answer 7

Hyperacute

Question 8

Hyperacute rejection is what type of hypersensitivity reaction

Answer 8

Type II

Question 9

Widespread thrombosis of graft vessels leading to ischemia and necrosis is seen in what type of transplant rejection

Answer 9

Hyperacute

Question 10

Acute rejection onset

Answer 10

Weeks to months

Question 11

Cellular response in acute rejection with mechanism

Answer 11

CD8+ T-cells activated against donor MHCI

Question 12

Type of hypersensitivity reaction in acute rejection involving a cellular response

Answer 12

Type IV

Question 13

Humoral response in acute rejection with mechanism

Answer 13

Antibodies develop after organ transplant and react to donor antigen

Question 14

Treatment for acute transplant rejection

Answer 14

Prevent/revers with immunosuppressants

Question 15

Vasculitis of graft vessels with dense interstitial lymphocytic infiltrate is seen in what type of transplant rejection

Answer 15

Acute

Question 16

What type of infiltrates are seen in acute transplant rejection

Answer 16

Lymphocytic infiltrate

Question 17

Chronic transplant rejection onset

Answer 17

Months to years

Question 18

What cells are involved in chronic transplant rejection

Answer 18

CD4+ T cells and APCs

Question 19

Mechanism of chronic transplant rejection

Answer 19

CD4+ T-cells respond to recipient APCs presenting donor peptides, including allogeneic MHC

Question 20

Broncholitis obliterans is seen in what type of transplant rejection

Answer 20

Chronic

Question 21

Accelerated atherosclerosis is seen in what type of transplant rejection

Answer 21

Chronic

Question 22

Chronic graft nephropathy is seen in what type of transplant rejection

Answer 22

Chronic

Question 23

Vanishing bile duct syndrome is seen in what type of transplant rejection

Answer 23

Chronic

Question 24

Chronic transplant rejection involves what type of hypersensitivity reaction

Answer 24

Bothe type II and type IV (cellular and humoral components)

Question 25

Recipeint T cells reacting and secreting cytokines leading to proliferation of vascular smooth muscle, parenchymal atrophy, interstitial fibrosis is seen in what type of transplant rejection

Answer 25

Chronic

Question 26

Transplant patient presents with maculopapular ras, jaundice and hepatosplenomegaly has what type of rejection

Answer 26

Graft-vs-host disease

Question 27

Onset of Graft-vs-host disease

Answer 27

Varies

Question 28

Graft-vs-host disease is what type of hypersensitivity reaction

Answer 28

Type IV

Question 29

Mechanism of graft-vs-host disease

Answer 29

Grafted immunocompetent T-cells proliferate in immunocompromised host and reject host cells with foreign proteins

Question 30

Outcome of graft-vs-host disease when grafted immunocompromised T-cells proliferate and reject host cells with foreign proteins

Answer 30

Severe organ dysfunction