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Flashcards in Adaptive response Deck (30):
1

describe features of APC

Strategic location (B and T cell interaction)
- Skin (SALT)
- Mucous membranes (GALT, NALT, BALT, GUALT)
- Lymphoid organs (Lymph nodes, spleen)
- Blood circulation (plasmacytoid and myeloid DCs)
What do they do?

• Pathogen capture
- Phagocytosis (whole microbe)
- Macropinocytosis (soluble particles)

• Diversity in pathogen sensors (PRRs)
- Extracellular pathogens (bacteria)
- Intracellular pathogens (viruses)

2

describe MHC molecules in relation to microbe presentation

.

3

Describe T cells and their role w/ infections

.

4

descibe B cell and antibody production w/ regards to infection

.

5

difference btw intracellular and extracellular microbes, give example of a microbe

intracellular divide in the cell (virus)
& vice versa

6

function of APC

Present Microbe to T cells

-theres an invader in the cell
-this is how it looks like
-& i want u to do this response

7

how do APC present pathogens to the T cells?

1) capture it (via phagocytosis and opsonisation)

2) process it

3) present it to T cell

8

what is the main strategic location (portal of entry, whereb and t cells interact) of the APC?

-MALT ( mucosal membrane associated tissues)

-TYPES>> galt, nalt, balt
-located in the lamina propria.

-they r aggregates of lymphoid tissue that have b & T cells.

9

function of spleen

can generate b & T cell response

10

difference btw primary and secondary lymphoid organs

Primary> Lymphocytes r generated, produced & educated there

Secondary>b & T cells r settled down there and wait for antigen to come ( chilling zone)

11

in what ways can APC capture Microbes?

-phagocytosis (whole microbe)

-macropinocytosis ( if it was soluble)

12

give 4 different types of APC's, their location, and what cep they present to

dentritic>>lymph nodes, musocus membranes, blood >>Naïve T cells

langerhans>>skin>>Naïve T cells

macrophages>>vary>>Effector T cells

B cells (BCR)>> lymph tissues>>Effector T cells Naïve T cells

13

what r naive t cells?

T cells that have not encountered an antigen is called a NAIVE T CELL

14

what r effector T cells

those naive T cells that have been activated by APC.

15

how do APC process the antigen?

done by a set of proteins called MHC (also called HLA)

16

Major Histocompatibility Complex (MHC) is ALSO called Human Leukocyte Antigen (HLA)

ok

17

what r 2 types of responses the adaptive immunity makes?

humoral & cell mediated

Extracellular microbes>APC> HUMORAL

Intracellular microbes> APC> cell mediated immunity

18

what r key players in the humoral & cell mediated immunity?

HUMORAL
Antibodies
Complement
Phagocytosis

CELL MEDIATED
Cytotoxic T lymphocytes Antibodies
Macrophages

19

Name types of MHC complexes and differentiate btw them

MHC I
-A, B, C
-TCR & CD8
-Found on all nucleated cells
-only present antigens from INTRACELLULAR MICROBES

MHC 2 (2 letters)
-DP, DQ, DR
-TCR & CD4
-Found on dendritic cells, macrophages, B cells (the APC cells)
-EXTRACELLULAR MICROBES

20

which MHC complex is found on dendritic cells, macrophages, B cells?

MHC 2

21

MHC 1 & 2 bind only to PEPTIDE antigens

ok

22

which MHC complexes only present antigens from INTRACELLULAR MICROBES

MHC 1

23

we have DIVERSE MHC complexes, why?

due to

-co-dominence
mama and baba BOTH have the gene

-they r highly polymorphic
each gene has different kinds>> INCREASED Diversity

24

Main functions of MHC 1 & 2

MHC Class I: present peptides from intracellular microbes

MHC Class II: present peptides from extracellular microbes

25

alaa know the structure of MHC class 1 & 2

ok

26

MHC class I recognized by ____T cells

MHC class II recognized by ____T cells

MHC class I recognized by CD8+ T cells

MHC class II recognized by CD4+ T cells

27

A 1st year medical student has contracted the flu virus during an immunology lecture. He has a terrible headache, fever and is coughing a lot.

1) The viral proteins on the airway epithelial cells are present by MHC molecules called HLA-DP, HLA-DQ, HLA-DR.
True or false?


2) His dendritic cells will also express the viral peptides
True or false?

1) F

2) T

28

virus r presented by MHC class____

1

29

how does streptokinase work?

dissolves clots through conversion of plasminogen to plasmin

30

functions of the antibodies?

notes