Adrenal pt 2 (week 9) Flashcards Preview

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Flashcards in Adrenal pt 2 (week 9) Deck (32):
1

Diseases caused by adrenal cortex hyperfunction

Cushings Syndrome
Conn's Syndrome
Adrenogenital Syndrome

2

Cushings Syndrome refers to an overproduction of

glucocorticoids (cortisol)

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over production of cortisol in Cushings Syndrome due to

-benign of malignant adenoma
-excess medication with corticosteroids
-excessive ACTH output from pituitary
-ectopic production of ACTH by a malignant tumor

4

pituitary adenoma

excessive ACTH output from pituitary caused by tumor

5

what is the most common cause of Cushings Syndrome

administration of excess corticosteroids

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what age range does Cushings Syndrome caused by adrenocortical tumors typically occur

20-40

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excessive levels of cortisol will lead to

-muscle wasting and weakness
-poor wound healing
-osteoporosis
-hyperglycemia
-depletion of potassium
-retention of sodium and water
-hypertension
-abnormal fat distribution
-susceptibility to infection
-increased androgens (virilization of women)
-mental changes

8

most common cause of Conn's Syndrome

benign tumor called aldosteronoma

9

What population does Conn's Syndrome typicalls occur in

females age 30-50; rare

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Is primary or secondary hyperaldosteronism more common?

secondary

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causes of secondary hyperaldosteronism

-reduced renal blood flow (renal artery stenosis)
-nephrotic syndrome (end stage renal disease)
-oral contraceptives (induces renal hypertension)
-congestive heart failure

12

most common cause of hyperaldosteronism

CHF

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treatment for hyperaldosteronism

diuretics

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symptoms of Conn's Syndrome

-hypernatremia
-hypertension
-hypokalemia
-diabetic symptoms (due to hypokalemia interfering with attachment to insulin receptors)
-metabolic alkalosis

15

treatment of Conn's Syndrome

resection of tumor
treat hypertension
correct hypokalemia
ACE inhibitors to prevent renal damage

16

Conn's Syndrome also known as

primary hyperaldosteronism

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treatment for Cushings Syndrome

resection of tumor
radiation

18

Cusings Syndrome can be caused by

intrinsic problems with adrenal cortex
intake of exogenous steroids (cross reactivity)

19

most common cause of hyperaldosteronism

CHF

20

Is primary or secondary hyperaldosteronism more common?

secondary

21

Conn's Syndrome also known as

primary hyperaldosteronism

22

treatment for Cushings Syndrome

resection of tumor
radiation

23

what is virilization of women

women grow facial hair, fat distribution changes to a more male pattern

24

why does potassium depletion occur in Cushings Syndrome

some cortisol will cross react and stimulate aldosterone receptors, which causes the body to retain sodium and water and excrete potassium

25

why does hyperglycemia occur in Cushings Syndrome

steroids increase release of glucose, therefore, Beta cells wear out trying to produce enough insulin to keep up

26

why does osteoporosis occur in Cushings Syndrome

the ratio of estrogens & progestins to glucocorticoids changes, which causes osteoporosis

27

why does poor wound healing occur in Cusings Syndrome

steroids decrease inflammatory and immune response

28

why does muscle wasting occur in Cushings Syndrome

excess cortisol promotes gluconeogenesis from protein to provide energy

29

Cusings Syndrome can be caused by

intrinsic problems with adrenal cortex
intake of exogenous steroids (cross reactivity)

29

most common cause of Conn's Syndrome

benign tumor called aldosteronoma

29

What population does Conn's Syndrome typicalls occur in

females age 30-50; rare

29

causes of secondary hyperaldosteronism

-reduced renal blood flow (renal artery stenosis)
-nephrotic syndrome (end stage renal disease)
-oral contraceptives (induces renal hypertension)
-congestive heart failure