HIV Part 2 (week 4) Flashcards Preview

Pathophysiology > HIV Part 2 (week 4) > Flashcards

Flashcards in HIV Part 2 (week 4) Deck (13):
1

window period

time between infection and appearance of antibodies

2

can patients be infectious even when they are serologically negative?

yes

3

how long can the early stage of HIV last?

10 years

4

what symptoms do patients have during early stages of HIV

mild symptoms similar to influenza
night sweats
swollen lymph glands
diarrhea
fatigue

5

how AIDS is diagnosed

CD4+T-cell count below 200 cells/cubic mm (normal: 800-1000)
presence of antibody against HIV
atypical or opportunistic infections and cancers
viral count (#virions/cubic mm)

6

average time from infection with HIV to developmet of AIDS

10 years

7

kaposi sarcoma

rare form of cancer, high incidence in AIDS population

8

HAART stands for

Highly Active Antiretroviral Therapy

9

what is HAART

pharmacological agents that will inhibit reverse transcriptionase and viral protease
has significantly decreased death from AIDS related disease

10

problems with HAART

HIV can mutate
negative side effects
may not be able to remove all HIV because it incorporates into cell DNA
If HIV exists in CNS, HAART cant get to it due to blood brain barrier

11

entrance inhibitors

attach to surface receptors targeted by HIV and prevent HIV attachment to host cell

12

other HIV treatments

entrance inhibitors
integrase inhibitors

13

problems with HIV vaccine

HIV mutates
antibodies produced by infected individuals seem to be ineffective in combating HIV
HIV spreads cell to cell so is often not accessible to antibody attack
no reliable animal model for research