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Pathophysiology > HIV > Flashcards

Flashcards in HIV Deck (15):
1

what type of virus is HIV

retrovirus

2

what glycoproteins are on the surface of HIV cells

gp120
gp41

3

what kinds of cells does HIV target

cells that have CD4 receptors or a cytokine receptor

4

types of cells that have CD4 receptors

CD4+Helper T cells
mononuclear phagocytes
B lymphocytes
neural cells of monocyte origin
dendritic cells (dementia)
bone marrow stromal cells
intestinal epithelial cells

5

process of HIV spread

-Binding
-Viral RNA enters cell
-Uncoating
-Reverse Transcriptionase
-Viral DNA enters cell nucleus
-Viral DNA inserted into DNA of host cell
-viral mRNA manufactured
-Viral mRNA provides manufacture of HIV structural proteins
-new HIV released from cell

6

what happens during binding phase

HIV binds to CD4 receptor or cytokine receptor and attaches utilizing gp120 and gp41

7

how does viral RNA enter host cell

it is enveloped in nucleocapsid

8

what happens during uncoating

viral RNA leaves the nucleocapsid

9

what happens during reverse transcriptionase

double stranded DNA manufactured from viral RNA template

10

what enzyme inserts viral DNA into DNA of host cell

integrase

11

Viral DNA can remain dormant for a long period of time. What happens when it is activated?

initiate translation of viral mRNA
begin production of HIV protein
This leads to formation of new virons, lysis, and death of host cell

12

primary immunologic effect of HIV

decline in number of helper T cells in body

13

how does HIV destroy helper T cells

-new viron production causes cell lysis
-HIV infected cells express new surface antigens and are attacked by other T cells
-shedding of the gp120 envelope protein can interact with other healthy T-cells, causing them to fuse and be destroyed

14

activated T cells are (more/less) susceptible to HIV attachment, invasion, and replication

more

15

what happens to T-cells when viral antigen present

they activate