Neoplastic Disorders (week 10) Flashcards Preview

Pathophysiology > Neoplastic Disorders (week 10) > Flashcards

Flashcards in Neoplastic Disorders (week 10) Deck (22):
1

neoplastic disease

includes many different diseases that occur due to accumulation of genetic changes due to heredity, environment, and behavior

2

what is a tumor

overgrowth of tissue independent to the controls that govern cell division and serves no use to the body

3

neoplasm

new tumor growth

4

what does cancer refer to

malignant tumor (aggressively expands and metastasizing)

5

characteristics of benign tumors

slow growers
not invasive to other tissues
encapsulated
cells do not divide rapidly
do not metastasize

6

characteristics of malignant tumors

grow rapidly
no encapsulation
rapid cell division
metastasize
invasive to local tissue
cross basement membranes

7

basement membrane

connective tissue structure that holds cells together, usually for a particular organ

8

carcinogenesis

initiation of cancer
multistage process

9

4 stages of carcinogenesis

initiation
promotion
transformation
progression

10

initiation

cell undergoes irreversible mutation

11

promotion

mutated cell divides and produces a tumor

12

transformation

mutated cells become cancerous (cells break off and metastasize)

13

progression

cell proliferation and tumor invasion into tissues

14

carcinoma

arising from epithelial tissue

15

adenocarcinoma

arising from ductal or glandular tissue

16

sarcoma

arising from connective tissue

17

lymphoma

arising from lymphatic tissue

18

leukemia

arising from blood forming tissue (marrow)

19

normal characteristics of cells

contact inhibition
anchorage dependent
limited life span
differentiation
glycoprotein markers on membrane

20

contact inhibition

cell division stops when dividing cells come into contact with other cells

21

anchorage dependent

cells remain attached to basement membrane

22

differentiation

specific purpose of cell