Anti Coag Drugs Flashcards Preview

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Flashcards in Anti Coag Drugs Deck (17):
1

Name the 8 antiplatelet drugs we learned

Aspirin
Clopidogrel
Ticlopidine
Prasugrel
Dipyridamole
Abcixamab
Eptifibabtide
Tirofiban

2

Which drugs are ADP receptor antagonist

Clopidogrel, Ticlopidine, Prasugrel

3

Abciximab, Eptifibatide, and Tirofiban all work via this mechanism

GPIIb/IIIa receptor inhibitor

4

Heparin potentiates this

Antithrombin III to inactivate Xa and IIA leads to no clotting

5

Direct Thrombins work via this mechanism

bind to thrombin and inhibit enzyme

6

Antidote for heparin?

Protamine - binds to neg. charged heparin and prevents its action

7

Describe the 3 types of indirect thrombin anti-coagualtion drugs

Unfractionated heparin - inactivate Xa and IIa
Low molecular weight heparin - inactivate Xa and some IIa
Fondaparinux - inactivate Xa - not reversed by protamine

8

Most common oral anticoagulation drug

Warfarin

9

Purpose of tPA drugs

activate plasminogen and dissolves thrombi

10

name the 4 direct thrombin drugs

Lepirudin
Bivalirudin
Argatroban
Dabigatran etexilate

11

How does Warfarin work?

Blocks synthesis of vitamin K dependent clotting factors

12

Antidote for warfarin?

Vitamin K (Phytonadione)

13

Describe the process of plasminogen and clot breakdown

plasminogen ---> plasmin, plasmin breaks clot down to FDP

14

Describe a pharmacodynamic effect between warfarin and the body

effect of drug on body
decrease platelet/clotting factors
decrease availability of vit. K

15

ADME describes the effects of the body on drugs also called this?

Pharmacokinetics

16

Warfarin works between these 2 proteins

precursors of prothrombin to prothrombin

17

2 drugs that have drug-drug interactions

Warfarin - multiple - CYPT 450
Clopodogrel - Cyp2A19 activation