Flashcards in Regulation of Immune Response Deck (14):
Which cytokines do TH-2 release?
IL-4, IL-5, IL-10, IL-13
Cytokines released by T-reg?
IL-10 and IL-35
Il-10, TNF and IFN alpha and gamma are released by these T cells
NKT cells release these cytokines
IL-2, IL-4, IFN-gamma, TNF
Describe the function of CCR7
Directs DC to lymph nodes and spleen.
Which factors lead to anergy
low (MHC, B7, CD40, CCR7)
B cell tolerance mechanisms include these possible outcomes
Ways T-regs regulate T cells
1. block cytokines and push into cell cycle arrest
2. Consume IL-2 and lead to apoptosis
3. release granzymes and cause apoptosis
4. Attach to DC and release kynurei which cause cell cycle arrest
What is IPEX?
immune disregulation poly endocrinopathy/enteropathy x-linked syndrome
Labs results seen in IPEX?
increased eosinophils and IgE
mutation in this gene causes IPEX
tf - FOX3P
lack of these cells in IPEX cause these systemic problems
Describe some physical manifestations of IPEX
watery diarrhea, FTT and dermatitis