Regulation of Immune Response Flashcards Preview

IHO Final > Regulation of Immune Response > Flashcards

Flashcards in Regulation of Immune Response Deck (14):
1

Which cytokines do TH-2 release?

IL-4, IL-5, IL-10, IL-13

2

Cytokines released by T-reg?

IL-10 and IL-35

3

Il-10, TNF and IFN alpha and gamma are released by these T cells

Tcytotoxic

4

NKT cells release these cytokines

IL-2, IL-4, IFN-gamma, TNF

5

Describe the function of CCR7

Directs DC to lymph nodes and spleen.

6

Which factors lead to anergy

low (MHC, B7, CD40, CCR7)
IL-10
TGF-beta

7

B cell tolerance mechanisms include these possible outcomes

apoptosis
receptor editing/recombination
anergy

8

Ways T-regs regulate T cells

1. block cytokines and push into cell cycle arrest
2. Consume IL-2 and lead to apoptosis
3. release granzymes and cause apoptosis
4. Attach to DC and release kynurei which cause cell cycle arrest

9

What is IPEX?

immune disregulation poly endocrinopathy/enteropathy x-linked syndrome

10

Labs results seen in IPEX?

increased eosinophils and IgE

11

mutation in this gene causes IPEX

tf - FOX3P

12

lack of these cells in IPEX cause these systemic problems

no Treg
autoimmune inflammation

13

Describe some physical manifestations of IPEX

watery diarrhea, FTT and dermatitis

14

Treatment of IPEX

immunosuppresion (cyclosporin, tacrilumis)
BMT