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Flashcards in anemia Deck (24):
1

Define WAHA

warm autoimmune hemolytic anemia

2

WAHA pearls

IgG
Spleen
Spherocytes

3

Define CAHA

cold autoimmunei hemolytic anemia

4

CAHA pearls

IgM, complement
Intravascular hemolysis
Agglutination

5

Clinical Signs of CAHA

Chronic hemolysis aggravated by cold
Pallor/cyanosis in cold body parts

6

What are Hemoglobinopathies?

Structurally abnormal hemoglobin - most important one is sickle cell anemis

7

Describe sickle beta chains

valine where a glutamate should be

8

Treatment of sickle crisis

Blood transfusion, BMT

9

Problems in Beta-thalassemia

defective transcription, translation, or mRNA processing of beta-chain

10

Thalassemia can look like this disorder

iron def. anemia
hypochromic, microcytic amnemia

11

Heinz body anemia refers to this

G6PD def.

12

Cause of Microangiopathic Hemolytic Anemis

Physical trauma to cells

13

Hallmark of Microangiopathic hemolytic anemia

triangulocyte

14

ACOD pearls

Infections, Inflammation, Malignancy
Iron metabolism disturbed
Mormochromic, normocytic
Usually mild

15

Anemia of Renal Disease Pearls

End stage renal failure
Lack of EPO
Echinocytes

16

Anemia of Liver Disease Pearls

Multiple causes, usually complicated
Acanthocytes

17

Aplastic Anemia disease Pearls

Pancytopenia
Empty marrow
Most are idiopathic

18

None idipathic causes of Aplastic anemia

Drugs
Viruses
Pregnancy
Fanconi anemia

19

For what anemias may you see spheroctyes?

WAHA, CAHA

20

Name the abnormal shape anemias

G6PD
Microangiopathic Hemolytic Anemia
Thallasemia
Hemoglobinoptahies
Anemia of Renal Disease
Anemia of LIver Disease

21

List some cause for Normocytic, normal shape RBC anemia

AOCD
Aplastic Anemia
Anemia of blood loss

22

How would you treat WAHA?

Steroids and splenectomy

23

Definitive diagnostic tool for distinguishing Hemoglobinapthies and Thallasemia

Hemoglobin Electrophoresis

24

Some aplastic anemia

Blood
G-CSF, Prednisone, AGD (immunosupprant)
Last resort - BMT