Flashcards in Leukemia Deck (18)
Percent of blasts needed to be diagnosed as leukemia
Name some genetic abnormalities seen in leukemias
This mutation is found in 1/3 of AML cases and involves a mutation of this tyrosine kinase
Disseminated Intravascular Coagulation
Faggot cells and DIC are indicative of this type of AML
When you see Auer rods think this...
Which AML types have the worst prognosis?
Therapy related leukemia
myeloplastic dysplagia syndrome
see abnormal stem cells often due to bone marrow failure
5 new classifications of AML
1. Genetic abnormalities
2. FLT-3 mutation
3. Multilineage dysplagia
4. Therapy related
5. Not otherwise classified
Extramedullary tumors are often seen in these types of AML
Name the AML that is MPO (-)
Which type of acute lymphoblastic leukemia is more desirable?
Which malignant hematopathologies originate in the lymphoid line?
leukemia (acute and chronic)
lymphoma (Hodgkin, non-Hodgkin)
Things that indicate a good prognosis for ALL
immunotype - B
Cells that stain with non-specific esterase
Neutrophils are stained with this.
Diagnosis of leukemia is done via these steps
1. Bone marrow biopsy
2. Morphology - stain
3. Flow cytometry
4. cytogenics - karotyping
5. molecular study