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Flashcards in Leukemia Deck (18):
1

Percent of blasts needed to be diagnosed as leukemia

20%

2

Name some genetic abnormalities seen in leukemias

11q23
t(8,21)
t(15,17)
inv(16)

3

This mutation is found in 1/3 of AML cases and involves a mutation of this tyrosine kinase

FLT-3

4

Define DIC

Disseminated Intravascular Coagulation

5

Faggot cells and DIC are indicative of this type of AML

AML-M3

6

When you see Auer rods think this...

AML-M1

7

Which AML types have the worst prognosis?

FLT-3 mutation
Multilineage Dysplasia
Therapy related leukemia

8

Define MDS

myeloplastic dysplagia syndrome
see abnormal stem cells often due to bone marrow failure

9

5 new classifications of AML

1. Genetic abnormalities
2. FLT-3 mutation
3. Multilineage dysplagia
4. Therapy related
5. Not otherwise classified

10

Extramedullary tumors are often seen in these types of AML

AML-4, AML-5

11

Name the AML that is MPO (-)

AML-M0

12

Which type of acute lymphoblastic leukemia is more desirable?

B-lymphoblatic leukemia

13

Which malignant hematopathologies originate in the lymphoid line?

leukemia (acute and chronic)
lymphoma (Hodgkin, non-Hodgkin)
multiple myeloma

14

Things that indicate a good prognosis for ALL

age: 1-10
WBC<10,000
hyperdiploidy
immunotype - B

15

Cells that stain with non-specific esterase

monocytes

16

Neutrophils are stained with this.

Myelo-peroxidase

17

Diagnosis of leukemia is done via these steps

1. Bone marrow biopsy
2. Morphology - stain
3. Flow cytometry
4. cytogenics - karotyping
5. molecular study

18

AML-M6 is dysplagia of this lineage of cells

erythroid